{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:12:25Z","timestamp":1769195545133,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Spinocerebellar ataxias (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado\u2013Joseph disease (<jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>) or spinocerebellar ataxia type 3 (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3)\u2014<jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3\u2014is the most common <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> worldwide. <jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3 is characterized classically by progressive ataxia and variable other motor and non\u2010motor symptoms. Sleep disorders are common, and include rapid eye movement (<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>) sleep behaviour disorder (<jats:styled-content style=\"fixed-case\">RBD<\/jats:styled-content>), restless legs syndrome (<jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content>), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea. This study aims to focus upon determining the presence or not of non\u2010<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content>)\u2010related parasomnias in <jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> 3, using data from polysomnography (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>) and clinical evaluation. Forty\u2010seven patients with clinical and genetic diagnosis of <jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3 and 47 control subjects were evaluated clinically and by polysomnography. <jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3 patients had a higher frequency of arousals from slow wave sleep (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), parasomnia complaints (confusional arousal\/sleep terrors, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001; <jats:styled-content style=\"fixed-case\">RBD<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00.001; and nightmares, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> sleep without atonia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), periodic limb movements of sleep index (<jats:styled-content style=\"fixed-case\">PLMS<\/jats:styled-content>i) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), percentage of N3 sleep (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and percentage of N1 sleep (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). These data show that <jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content>\u2010related parasomnias must be included in the spectrum of sleep disorders in <jats:styled-content style=\"fixed-case\">MJD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>3 patients.<\/jats:p>","DOI":"10.1111\/jsr.12330","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T12:52:55Z","timestamp":1441284775000},"page":"11-15","source":"Crossref","is-referenced-by-count":22,"title":["NREM\u2010related parasomnias in Machado\u2013Joseph disease: clinical and polysomnographic evaluation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-0330","authenticated-orcid":false,"given":"Giselle Melo Fontes","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luiz","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo Fernandes","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Braga\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila Bizari Fernandes","family":"Do Prado","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Bizari Coin","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando G. P.","family":"Barsottini","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilmar Fernandes","family":"Do Prado","sequence":"additional","affiliation":[{"name":"Department of Neurology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"e_1_2_7_3_1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02561-7"},{"key":"e_1_2_7_5_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Berry R. B.","year":"2012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2010000200014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.02.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0318-6"},{"key":"e_1_2_7_9_1","first-page":"A325","article-title":"The value of the unexplained polysomnographic arousal from slow\u2010wave sleep in predicting sleepwalking and sleep terrors in a sleep laboratory patient population","volume":"26","author":"Brozen B.","year":"2003","journal-title":"Sleep"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.09.025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00249-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/23.6.1d","article-title":"Dynamics of slow\u2010wave activity during the NREM sleep of sleepwalkers and control subjects","volume":"23","author":"Gaudreau H.","year":"2000","journal-title":"Sleep"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2011.04.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01045-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.936"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2008.09.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000600011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0653-2_14"},{"key":"e_1_2_7_20_1","first-page":"333","article-title":"Parasomnias: an overview","volume":"131","author":"Matwiyoff G.","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.05.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0489-0"},{"key":"e_1_2_7_23_1","first-page":"447","article-title":"Neurophysiological studies and non\u2010motor symptoms prior to ataxia in a patient with Machado\u2010Joseph disease: trying to understand the natural history of brain degeneration","volume":"13","author":"Pedroso J. L.","year":"2014","journal-title":"Cerebellum"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.05.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.09.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2011000200021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2012000800013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25513"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.4.706"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03034.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282f7673d"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45013-9"},{"key":"e_1_2_7_34_1","first-page":"2286","article-title":"The REM sleep behavior disorder screening questionnaire\u2014a new diagnostic instrument","volume":"22","author":"Stiany\u2010Kolster K.","year":"2007","journal-title":"Mov. Disord."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00231-6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23584"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216120-00002"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:34:41Z","timestamp":1696221281000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jsr.12330"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12330","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,3]]}}}