{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:29:35Z","timestamp":1790537375322,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The present study sought to investigate whether a single night of partial sleep deprivation (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>) would alter fasting insulin sensitivity and cephalic phase insulin release (<jats:styled-content style=\"fixed-case\">CPIR<\/jats:styled-content>) in humans. A rise in circulating insulin in response to food\u2010related sensory stimulation may prepare tissues to break down ingested glucose, e.g. by stimulating rate\u2010limiting glycolytic enzymes. In addition, given insulin's anorexigenic properties once it reaches the brain, the <jats:styled-content style=\"fixed-case\">CPIR<\/jats:styled-content> may serve as an early peripheral satiety signal. Against this background, in the present study 16 men participated in two separate sessions: one night of <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> (4.25\u00a0h sleep) versus one\u00a0night of full sleep (8.5\u00a0h sleep). In the morning following each sleep condition, subjects\u2019 oral cavities were rinsed with a 1\u2010molar sucrose solution for 45\u00a0s, preceded and followed by blood sampling for repeated determination of plasma glucose and serum insulin concentrations (\u22123, +3, +5, +7, +10 and +20\u00a0min). Our main result was that <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>, compared with full sleep, was associated with significantly higher peripheral insulin resistance, as indicated by a higher fasting homeostasis model assessment of insulin resistance index (+16%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025). In contrast, no <jats:styled-content style=\"fixed-case\">CPIR<\/jats:styled-content> was observed in any of the two sleep conditions. Our findings indicate that a single night of <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> is already sufficient to impair fasting insulin sensitivity in healthy men. In contrast, brief oral cavity rinsing with sucrose solution did not change serum insulin concentrations, suggesting that a blunted <jats:styled-content style=\"fixed-case\">CPIR<\/jats:styled-content> is an unlikely mechanism through which acute sleep loss causes metabolic perturbations during morning hours in humans.<\/jats:p>","DOI":"10.1111\/jsr.12340","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T05:55:13Z","timestamp":1441950913000},"page":"5-10","source":"Crossref","is-referenced-by-count":59,"title":["A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men"],"prefix":"10.1111","volume":"25","author":[{"given":"Jonathan","family":"Cedernaes","sequence":"first","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala 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