{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:33:05Z","timestamp":1788885185731,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of this study was to evaluate the levels of plasma bicarbonate levels in narcoleptic children. Clinical, electrophysiological data and bicarbonate levels were evaluated retrospectively in children seen in our paediatric national reference centre for hypersomnia. The cohort included 23 control subjects (11.5\u00a0\u00b1\u00a04\u00a0years, 43% boys) and 51 patients presenting <jats:italic>de\u2010novo<\/jats:italic> narcolepsy (N) (12.7\u00a0\u00b1\u00a03.7\u00a0years, 47% boys). In narcoleptic children, cataplexy was present in 78% and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*0602 was positive in 96%. The control children were less obese (2 versus 47%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Compared with control subjects, narcoleptic children had higher bicarbonate levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) as well as higher <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content><jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and lower venous <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> gas (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Bicarbonate levels higher than 27\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> were found in 41.2% of the narcoleptic children and 4.2% of the controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Bicarbonate levels were correlated with the Adapted Epworth Sleepiness Scale (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Narcoleptic patients without obesity often had bicarbonate levels higher than 27\u00a0mmol\u00a0L <jats:sup>\u22121<\/jats:sup> (55 versus 25%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.025). No differences were found between children with and without cataplexy. In conclusion, narcoleptic patients had higher bicarbonate plasma levels compared to control children. This result could be a marker of hypoventilation in this pathology, provoking an increase in <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content><jats:sub>2<\/jats:sub> and therefore a respiratory acidosis, compensated by an increase in plasma bicarbonates. This simple screening tool could be useful for prioritizing children for sleep laboratory evaluation in practice.<\/jats:p>","DOI":"10.1111\/jsr.12357","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T12:03:06Z","timestamp":1447761786000},"page":"194-202","source":"Crossref","is-referenced-by-count":5,"title":["High bicarbonate levels in narcoleptic children"],"prefix":"10.1111","volume":"25","author":[{"given":"Patricia","family":"Franco","sequence":"first","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy Idiopathic Hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2013hypersomnie) Lyon France"},{"name":"Pediatric Sleep Unit H\u00f4pital Femme M\u00e8re Enfant University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Junqua","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy Idiopathic Hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2013hypersomnie) Lyon France"},{"name":"Pediatric Sleep Unit H\u00f4pital Femme M\u00e8re Enfant University Lyon1 Lyon France"},{"name":"Service d'Hormonologie, Groupement Est Universit\u00e9 Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guignard\u2010Perret","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy Idiopathic Hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2013hypersomnie) Lyon France"},{"name":"Pediatric Sleep Unit H\u00f4pital Femme M\u00e8re Enfant University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Raoux","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy Idiopathic Hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2013hypersomnie) Lyon France"},{"name":"Pediatric Sleep Unit H\u00f4pital Femme M\u00e8re Enfant University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Perier","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Raverot","sequence":"additional","affiliation":[{"name":"Service d'Hormonologie, Groupement Est Universit\u00e9 Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Claustrat","sequence":"additional","affiliation":[{"name":"Service d'Hormonologie, Groupement Est Universit\u00e9 Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Gustin","sequence":"additional","affiliation":[{"name":"Department of Public Health Institute of Pharmacy and Service de Biostatistique University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Odilia","family":"Inocente","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Integrative Physiology of Brain Arousal System CRNL INSERM\u2010U1028 University Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The International Classification of Sleep Disorders, 2nd edn. 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