{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:51:08Z","timestamp":1771548668118,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Current treatment recommendations for narcolepsy suggest that modafinil should be used as a first\u2010line treatment ahead of conventional stimulants or sodium oxybate. In this study, performed in a tertiary sleep disorders centre, treatment responses were examined following these recommendations, and the ability of sleep\u2010stage sequencing of sleep\u2010onset rapid eye movement periods in the multiple sleep latency test to predict treatment response. Over a 3.5\u2010year period, 255 patients were retrospectively identified in the authors' database as patients diagnosed with narcolepsy, type 1 (with cataplexy) or type 2 (without) using clinical and polysomnographic criteria. Eligible patients were examined in detail, sleep study data were abstracted and sleep\u2010stage sequencing of sleep\u2010onset rapid eye movement periods were analysed. Response to treatment was graded utilizing an internally developed scale. Seventy\u2010five patients were included (39% males). Forty (53%) were diagnosed with type 1 narcolepsy with a mean follow\u2010up of 2.37\u00a0\u00b1\u00a01.35\u00a0years. Ninety\u2010seven percent of the patients were initially started on modafinil, and overall 59% reported complete response on the last follow\u2010up. Twenty\u2010nine patients (39%) had the sequence of sleep stage 1 or wake to rapid eye movement in all of their sleep\u2010onset rapid eye movement periods, with most of these diagnosed as narcolepsy type 1 (72%). The presence of this specific sleep\u2010stage sequence in all sleep\u2010onset rapid eye movement periods was associated with worse treatment response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0023). Sleep\u2010stage sequence analysis of sleep\u2010onset rapid eye movement periods in the multiple sleep latency test may aid the prediction of treatment response in narcoleptics and provide a useful prognostic tool in clinical practice, above and beyond their classification as narcolepsy type 1 or 2.<\/jats:p>","DOI":"10.1111\/jsr.12363","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T06:42:37Z","timestamp":1446792157000},"page":"203-210","source":"Crossref","is-referenced-by-count":9,"title":["Sleep\u2010stage sequencing of sleep\u2010onset REM periods in MSLT predicts treatment response in patients with narcolepsy"],"prefix":"10.1111","volume":"25","author":[{"given":"Panagis","family":"Drakatos","sequence":"first","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishankumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiraag","family":"Thakrar","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"},{"name":"Professor in Sleep Medicine King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Kent","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy D.","family":"Leschziner","sequence":"additional","affiliation":[{"name":"Sleep Disorders Centre Guy's and St Thomas Hospital London UK"},{"name":"Department of Clinical Neuroscience King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"620","article-title":"Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy","volume":"20","author":"Aldrich M. 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