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Those distinct morphometric changes account for problems in wake\u2013sleep control, attention and memory. It also raised the necessity to evaluate white matter changes. To investigate brain white matter alterations in drug\u2010na\u00efve narcolepsy patients with cataplexy and to explore relationships between white matter changes and patient clinical characteristics, drug\u2010na\u00efve narcolepsy patients with cataplexy (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) and healthy age\u2010 and gender\u2010matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) were studied. Fractional anisotropy and mean diffusivity images were obtained from whole\u2010brain diffusion tensor imaging, and tract\u2010based spatial statistics were used to localize white matter abnormalities. Compared with controls, patients showed significant decreases in fractional anisotropy of white matter of the bilateral anterior cingulate, fronto\u2010orbital area, frontal lobe, anterior limb of the internal capsule and corpus callosum, as well as the left anterior and medial thalamus. Patients and controls showed no differences in mean diffusivity. Among patients, mean diffusivity values of white matter in the bilateral superior frontal gyri, bilateral fronto\u2010orbital gyri and right superior parietal gyrus were positively correlated with depressive mood. This tract\u2010based spatial statistics study demonstrated that drug\u2010na\u00efve patients with narcolepsy had reduced fractional anisotropy of white matter in multiple brain areas and significant relationship between increased mean diffusivity of white matter in frontal\/cingulate and depression. It suggests the widespread disruption of white matter integrity and prevalent brain degeneration of frontal lobes according to a depressive symptom in narcolepsy.<\/jats:p>","DOI":"10.1111\/jsr.12366","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T04:59:08Z","timestamp":1448600348000},"page":"181-189","source":"Crossref","is-referenced-by-count":39,"title":["White matter alterations in narcolepsy patients with cataplexy: tract\u2010based spatial statistics"],"prefix":"10.1111","volume":"25","author":[{"given":"Yun K.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology Neuroscience Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oh\u2010Hun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Computational NeuroImage Analysis Laboratory Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Yeon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Department of Health Sciences and Technology SAIHST Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Computational NeuroImage Analysis Laboratory Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung B.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Neuroscience Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Department of Health Sciences and Technology SAIHST Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Andersson J. 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