{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:23:52Z","timestamp":1775787832959,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UCB Pharma Europe"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This two\u2010centre observational study of vigilance measurements assessed the feasibility of vigilance measurements on multiple days using the Sustained Attention to Response Task and the Psychomotor Vigilance Test with portable task equipment, and subsequently assessed the effect of sodium oxybate treatment on vigilance in patients with narcolepsy. Twenty\u2010six patients with narcolepsy and 15 healthy controls were included. The study comprised two in\u2010laboratory days for the Maintenance of Wakefulness Test and the Oxford Sleep Resistance test, followed by 7\u2010day portable vigilance battery measurements. This procedure was repeated for patients with narcolepsy after at least 3\u00a0months of stable treatment with sodium oxybate. Patients with narcolepsy had a higher Sustained Attention to Response Task error count, lower Psychomotor Vigilance Test reciprocal reaction time, higher Oxford Sleep Resistance test omission error count adjusted for test duration (Oxford Sleep Resistance test<jats:styled-content style=\"fixed-case\"><jats:sub>OMIS<\/jats:sub><\/jats:styled-content><jats:sub>\/<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>MIN<\/jats:sub><\/jats:styled-content>), and lower Oxford Sleep Resistance test and Maintenance of Wakefulness Test sleep latency compared with controls (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Treatment with sodium oxybate was associated with a longer Maintenance of Wakefulness Test sleep latency (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), lower Oxford Sleep Resistance test<jats:styled-content style=\"fixed-case\"><jats:sub>OMIS<\/jats:sub><\/jats:styled-content><jats:sub>\/<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>MIN<\/jats:sub><\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and a lower Sustained Attention to Response Task error count (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) in patients with narcolepsy, but not with absolute changes in Oxford Sleep Resistance test sleep latency or Psychomotor Vigilance Test reciprocal reaction time. It was concluded that portable measurements of sustained attention as well as in\u2010laboratory Oxford Sleep Resistance test and Maintenance of Wakefulness Test measurements revealed worse performance for narcoleptic patients compared with controls, and that sodium oxybate was associated with an improvement of sustained attention and a better resistance to sleep.<\/jats:p>","DOI":"10.1111\/jsr.12386","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T05:14:34Z","timestamp":1456377274000},"page":"486-496","source":"Crossref","is-referenced-by-count":29,"title":["Improved vigilance after sodium oxybate treatment in narcolepsy: a comparison between in\u2010field and in\u2010laboratory measurements"],"prefix":"10.1111","volume":"25","author":[{"given":"Mojca K. M.","family":"van Schie","sequence":"first","affiliation":[{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Werth","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert Jan","family":"Lammers","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Overeem","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center Kempenhaeghe Heeze The Netherlands"},{"name":"University of Technology Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian R.","family":"Baumann","sequence":"additional","affiliation":[{"name":"University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Fronczek","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"International Classification of Sleep Disorders. 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