{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:14:29Z","timestamp":1762866869837},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Histamine and orexins are wake promoters released by hypothalamic neurons. The activity of histamine neurons is increased by orexin neurons. Recently, it has been shown that orexin deficiency entails high\u2010amplitude theta wave bursts during rapid eye movement sleep and cataplexy in narcoleptic mice. The primary aim of this study was to assess whether histamine system is involved in high\u2010amplitude theta wave burst generation during rapid eye movement sleep. The secondary aim was to assess the effects of combined histamine and orexin deficiency on high\u2010amplitude theta wave bursts during rapid eye movement sleep in mice. Twelve histidine\u2010decarboxylase knockout mice with congenital histamine deficiency, seven double mutant mice with combined deficiency of orexin neurons and histamine, and 11 wild\u2010type control mice were studied with electrodes for sleep recordings and a telemetric blood pressure transducer. High\u2010amplitude theta wave bursts during rapid eye movement sleep were detected in each of the histidine\u2010decarboxylase knockout and double mutant mice, whereas only one burst was found in a wild\u2010type control mouse. High\u2010amplitude theta wave bursts occurred significantly more often and were significantly longer in double mutant than in histidine\u2010decarboxylase knockout mice. In conclusion, it was demonstrated that, similarly to orexin, the chronic impairment of histamine entailed high\u2010amplitude theta wave bursts during rapid eye movement sleep. The current data also suggested a synergistic role of orexin and histamine signalling on high\u2010amplitude theta wave bursts during rapid eye movement sleep in mice.<\/jats:p>","DOI":"10.1111\/jsr.12404","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T05:35:42Z","timestamp":1464327342000},"page":"591-595","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010amplitude theta wave bursts characterizing narcoleptic mice and patients are also produced by histamine deficiency in mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Stefano","family":"Bastianini","sequence":"first","affiliation":[{"name":"Laboratory of Physiological Regulations in Sleeping Mice (PRISM) Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Lo Martire","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Regulations in Sleeping Mice (PRISM) Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Berteotti","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Regulations in Sleeping Mice (PRISM) Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Silvani","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Regulations in Sleeping Mice (PRISM) Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Applied Quantum Medical Engineering Graduate School of Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Physiologie int\u00e9gr\u00e9e du syst\u00e8me d'\u00e9veil Centre de recherche en neurosciences de Lyon INSERM U1028\u2010CNRS UMR 5292 Facult\u00e9 de M\u00e9decine Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Zoccoli","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Regulations in Sleeping Mice (PRISM) Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.12.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03596.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.2.213"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00945.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.07.018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140520"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00039-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81973-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.09.045"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2114"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90092-T"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03243.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00293-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181330998"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23968"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.181"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2000.0116"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.12.003"},{"key":"e_1_2_6_20_1","first-page":"77","article-title":"High amplitude theta wave bursts: a novel electroencephalographic feature of REM sleep and cataplexy","volume":"153","author":"Lo Martire V.","year":"2015","journal-title":"Arch. 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