{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:35:09Z","timestamp":1790512509006,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital General de M\u00e9xico","award":["DI\/12\/403\/04\/003"],"award-info":[{"award-number":["DI\/12\/403\/04\/003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The amygdaloid complex plays a crucial role in processing emotional signals and in the formation of emotional memories. Neuroimaging studies have shown human amygdala activation during rapid eye movement sleep (\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    ). Stereotactically implanted electrodes for presurgical evaluation in epileptic patients provide a unique opportunity to directly record amygdala activity. The present study analysed amygdala activity associated with\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep eye movements on the millisecond scale. We propose that phasic activation associated with rapid eye movements may provide the amygdala with endogenous excitation during\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep. Standard polysomnography and stereo\u2010electroencephalograph (\n                    <jats:styled-content style=\"fixed-case\">SEEG<\/jats:styled-content>\n                    ) were recorded simultaneously during spontaneous sleep in the left amygdala of four patients. Time\u2013frequency analysis and absolute power of gamma activity were obtained for 250\u00a0ms time windows preceding and following eye movement onset in\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep, and in spontaneous waking eye movements in the dark. Absolute power of the 44\u201348\u00a0Hz band increased significantly during the 250\u00a0ms time window after\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep rapid eye movements onset, but not during waking eye movements. Transient activation of the amygdala provides physiological support for the proposed participation of the amygdala in emotional expression, in the emotional content of dreams and for the reactivation and consolidation of emotional memories during\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep, as well as for next\u2010day emotional regulation, and its possible role in the bidirectional interaction between\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep and such sleep disorders as nightmares, anxiety and post\u2010traumatic sleep disorder. These results provide unique, direct evidence of increased activation of the human amygdala time\u2010locked to\n                    <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>\n                    sleep rapid eye movements.\n                  <\/jats:p>","DOI":"10.1111\/jsr.12415","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T03:20:30Z","timestamp":1462418430000},"page":"576-582","source":"Crossref","is-referenced-by-count":74,"title":["Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study"],"prefix":"10.1111","volume":"25","author":[{"given":"Mar\u00eda","family":"Corsi\u2010Cabrera","sequence":"first","affiliation":[{"name":"Laboratorio de Sue\u00f1o Facultad de Psicolog\u00eda Posgrado Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Velasco","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Epilepsia Unidad de Neurocirug\u00eda Funcional Estereotaxia y Radiocirug\u00eda Hospital General de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"del R\u00edo\u2010Portilla","sequence":"additional","affiliation":[{"name":"Laboratorio de Sue\u00f1o Facultad de Psicolog\u00eda Posgrado Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Armony","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Douglas Health Institute McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Trejo\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Epilepsia Unidad de Neurocirug\u00eda Funcional Estereotaxia y Radiocirug\u00eda Hospital General de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Guevara","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias Universidad de Guadalajara M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Velasco","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Epilepsia Unidad de Neurocirug\u00eda Funcional Estereotaxia y Radiocirug\u00eda Hospital General de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8425.2008.00332.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00012-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/ccog.1995.1039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1754073912457208"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00711551"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/7.3.202"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199601310-00048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.052"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801819105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8425.2006.00202.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199812)30:4<409::AID-SYN8>3.0.CO;2-#"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-3832-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.concog.2010.10.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn915"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg091"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90075-Y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.2078"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/383163a0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.10.020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1579-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.12.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00807-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00809.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.025"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.10.1.83"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-11-200606060-00004"},{"key":"e_1_2_8_30_1","first-page":"192","article-title":"REM sleep post\u2010eye movement activation","volume":"10","author":"R\u00edo\u2010Portilla Y.","year":"2008","journal-title":"Int. J. Bioelectromagn."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1962.01720040001001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.04.334"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2012.00025"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00142"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703084104"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.11.011"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/sleep\/26.3.259","article-title":"Long\u2010lasting enhancement of rapid eye movement sleep and pontogeniculooccipital waves by vasoactive intestinal peptide microinjection into the amygdala temporal lobe","volume":"26","author":"Sim\u00f3n\u2010Arceo K.","year":"2003","journal-title":"Sleep"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21369"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.10.052"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05314.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-3850-z"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:57:28Z","timestamp":1696172248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/jsr.12415"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12415","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,5]]}}}