{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:02:24Z","timestamp":1787734944934,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Philips Respironics PLC"},{"name":"ResMed PLC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The cross\u2010sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate &lt;60\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\u00a0min<jats:sup>\u22121<\/jats:sup>\u22191.73\u00a0m<jats:sup>\u22122<\/jats:sup>, was investigated in a large cohort of patients with suspected obstructive sleep apnea studied by nocturnal polysomnography or cardiorespiratory polygraphy. Data were obtained from the European Sleep Apnea Database, where information from unselected adult patients with suspected obstructive sleep apnea afferent to 26 European sleep centres had been prospectively collected. Both the Modification of Diet in Renal Disease and the Chronic Kidney Disease\u2010Epidemiology Collaboration equations were used for the assessment of estimated glomerular filtration rate. The analysed sample included 7700 subjects, 71% male, aged 51.9\u00a0\u00b1\u00a012.5\u00a0years. Severe obstructive sleep apnea (apnea\u2013hypopnea index \u226530) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81\u00a0\u00b1\u00a010.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease\u2010Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co\u2010morbidities (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, each). With both equations, independent predictors of estimated glomerular filtration rate &lt;60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co\u2010morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.<\/jats:p>","DOI":"10.1111\/jsr.12426","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T09:29:27Z","timestamp":1463563767000},"page":"739-745","source":"Crossref","is-referenced-by-count":63,"title":["Chronic kidney disease in European patients with obstructive sleep apnea: the <scp>ESADA<\/scp> cohort study"],"prefix":"10.1111","volume":"25","author":[{"given":"Oreste","family":"Marrone","sequence":"first","affiliation":[{"name":"CNR Institute of Biomedicine and Molecular Immunology Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[{"name":"DiBiMIS University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paschalis","family":"Steiropoulos","sequence":"additional","affiliation":[{"name":"Sleep Unit Department of Pneumology Democritus University of Thrace Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozen K.","family":"Basoglu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Ege University School of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kvamme","sequence":"additional","affiliation":[{"name":"ENT Department F\u00f8rde Central Hospital F\u00f8rde Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"},{"name":"Pulmonary and Sleep Disorders Unit St Vincent's University Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Pepin","sequence":"additional","affiliation":[{"name":"INSERM, Laboratoire HP2, and CHU de Grenoble, P\u00f4le Thorax et Vaisseaux Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Verbraecken","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Disorders Centre Antwerp University Hospital and University of Antwerp Edegem\u2010Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[{"name":"Sleep Medicine Sahlgrenska University Hospital and Sahlgrenska Academy Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[{"name":"Sleep Medicine Sahlgrenska University Hospital and Sahlgrenska Academy Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Bonsignore","sequence":"additional","affiliation":[{"name":"CNR Institute of Biomedicine and Molecular Immunology Palermo Italy"},{"name":"DiBiMIS University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ESADA study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"915","DOI":"10.5664\/jcsm.4946","article-title":"Obstructive sleep apnea and kidney disease: a potential bidirectional relationship?","volume":"11","author":"Abuyassin B.","year":"2015","journal-title":"J. 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