{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:19:20Z","timestamp":1778894360891,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003919","name":"Kleine-Levin Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Previous studies have indicated involvement of the thalamus and the pons in Kleine\u2013Levin syndrome. In the present study, functional connectivity of the thalamus and the pons was investigated in asymptomatic patients with Kleine\u2013Levin syndrome and healthy controls. Twelve patients and 14 healthy controls were investigated by functional magnetic resonance imaging during rest. Resting state images were analysed using seed regions of interest in the thalamus and the pons. The results showed significantly lower functional connectivity between the pons and the frontal eye field in persons with Kleine\u2013Levin syndrome compared with healthy controls. There were no connectivity differences involving the thalamus. Based on these findings, a relation is proposed between the sleep disorder Kleine\u2013Levin syndrome and cerebral control of eye movements, which in turn is related to visual attention and working memory. This hypothesis has to be tested in future studies of oculomotor control in Kleine\u2013Levin syndrome.<\/jats:p>","DOI":"10.1111\/jsr.12428","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T05:35:48Z","timestamp":1464327348000},"page":"716-719","source":"Crossref","is-referenced-by-count":6,"title":["New hypothesis on pontine\u2013frontal eye field connectivity in Kleine\u2013Levin syndrome"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-2450","authenticated-orcid":false,"given":"Maria","family":"Engstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Medical and Health Sciences (IMH) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Center for Medical Image Science and Visualization (CMIV) Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie","family":"Landtblom","sequence":"additional","affiliation":[{"name":"Center for Medical Image Science and Visualization (CMIV) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Neurology Department of Clinical and Experimental Medicine (IKE) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Medical Specialist Department of Clinical and Experimental Medicine (IKE) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Neuroscience\/Neurology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Center for Medical Image Science and Visualization (CMIV) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Behavioral Science and Learning Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh620"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7644-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80593-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093813"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.05.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.5.681"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00140"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3420"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Reduced thalamic and pontine connectivity in Kleine\u2010Levin syndrome","volume":"5","author":"Engstr\u00f6m M.","year":"2014","journal-title":"Front. 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