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The dopamine agonist pramipexole is currently indicated for the symptomatic treatment of restless legs. The effect of pramipexole on sleep bruxism was investigated in subjects with \u2018probable bruxism\u2019 recruited at the Orofacial Pain Clinic. Thirteen patients underwent polysomnographic recordings, including bilateral masseter electromyographic activity. Following habituation to the recording equipment, a baseline registration was used to confirm bruxism [total episodes per hour, mean 11.3 (6.3)]. Following randomisation, subjects received no treatment or pramipexole titrated from 0.09 to 0.54\u00a0mg, o.d., for 3\u00a0weeks according to a crossover procedure. A polysomnographic\u2010electromyographic registration was performed at the end of each period. Pramipexole was associated with more frequent awakenings and a reduction in rapid eye movement sleep (both <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a00.02). Sleep apnea decreased marginally after pramipexole (apnea\u2013hypopnea index 17.1 compared with control 21.5, <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a00.05). The number of bruxism episodes, phasic, tonic and mixed per hour, remained unchanged after pramipexole [total episodes per hour 12.7 (8.5) and 9.8 (5.2) during pramipexole and control conditions, respectively]. It is concluded, from this pilot study, that sleep bruxism is not affected by the dopaminergic agent, pramipexole.<\/jats:p>","DOI":"10.1111\/jsr.12440","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T02:42:42Z","timestamp":1468809762000},"page":"64-72","source":"Crossref","is-referenced-by-count":21,"title":["A randomised, open\u2010label, crossover study of the dopamine agonist, pramipexole, in patients with sleep bruxism"],"prefix":"10.1111","volume":"26","author":[{"given":"Birgitta Johansson","family":"Cahlin","sequence":"first","affiliation":[{"name":"Department of Behavioral and Community Dentistry Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Dahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Behavioral and Community Dentistry Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"e_1_2_8_3_1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_8_4_1","volume-title":"ICSD \u2013 International Classification of Sleep Disorders: Diagnostic and Coding Manual","author":"American Sleep Disorders Association","year":"1990"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.1999.0070"},{"key":"e_1_2_8_6_1","unstructured":"Berry R. 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