{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:33:23Z","timestamp":1770136403419,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Splitting of the behavioural activity phase has been found in nocturnal rodents with suprachiasmatic nucleus (<jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>) coupling disorder. A similar phenomenon was observed in the sleep phase in the diurnal human discussed here, suggesting that there are so\u2010called evening and morning oscillators in the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> of humans. The present case suffered from bipolar disorder refractory to various treatments, and various circadian rhythm sleep disorders, such as delayed sleep phase, polyphasic sleep, separation of the sleep bout resembling splitting and circabidian rhythm (48\u00a0h), were found during prolonged depressive episodes with hypersomnia. Separation of sleep into evening and morning components and delayed sleep\u2010offset (24.69\u2010h cycle) developed when lowering and stopping the dose of aripiprazole (<jats:styled-content style=\"fixed-case\">APZ<\/jats:styled-content>). However, resumption of <jats:styled-content style=\"fixed-case\">APZ<\/jats:styled-content> improved these symptoms in 2\u00a0weeks, accompanied by improvement in the patient's depressive state. Administration of <jats:styled-content style=\"fixed-case\">APZ<\/jats:styled-content> may improve various circadian rhythm sleep disorders, as well as improve and prevent manic\u2013depressive episodes, via augmentation of coupling in the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> network.<\/jats:p>","DOI":"10.1111\/jsr.12496","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T06:34:53Z","timestamp":1485239693000},"page":"247-250","source":"Crossref","is-referenced-by-count":11,"title":["Improvement of a patient's circadian rhythm sleep disorders by aripiprazole was associated with stabilization of his bipolar illness"],"prefix":"10.1111","volume":"26","author":[{"given":"Tetsuo","family":"Tashiro","sequence":"first","affiliation":[{"name":"Tashiro Clinic Akita\u2010heal Medical Corporation Akita City Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90465-Y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06128.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/4.1.1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811410106"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6444.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.12.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300203"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404273432"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-6-1276"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:06:32Z","timestamp":1696525592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jsr.12496"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12496","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}