{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:29Z","timestamp":1791580169458,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vestibular dysfunction was linked to moderate\u2010to\u2010severe obstructive sleep apnea syndrome (<jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>) patients in literature. However, due to a lack of knowledge among valid and recent implementations conceived to study postural control on static posturography (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) and vestibulo\u2010ocular reflex (<jats:styled-content style=\"fixed-case\">VOR<\/jats:styled-content>) gain under physiological conditions (video Head Impulse Test; <jats:styled-content style=\"fixed-case\">vHIT<\/jats:styled-content>), the aim of this work was to integrate (i) <jats:styled-content style=\"fixed-case\">VOR<\/jats:styled-content> changes via <jats:styled-content style=\"fixed-case\">vHIT<\/jats:styled-content> implementation, (ii) postural arrangement by studying both classical parameters and frequency spectra (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) and (iii) correlation between these findings, polygraphic (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) and subjective scores along Dizziness Handicap Inventory (<jats:styled-content style=\"fixed-case\">DHI<\/jats:styled-content>) and Epworth Sleepiness Scale (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>). Thus, 32 moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content> patients and 32 healthy subjects \u2013 studied by using <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DHI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content> \u2013 underwent <jats:styled-content style=\"fixed-case\">vHIT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> posturographic assessment. Analysis of variance was performed to disclose between\u2010group effects and correlation analysis was implemented between otoneurological, <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DHI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content> values. <jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content> group demonstrated a significant decay of <jats:styled-content style=\"fixed-case\">VOR<\/jats:styled-content> gain and an increase in both frequency spectra <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> values, especially within the low\u2010frequency interval, and in classical posturographic <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> parameters. Further, positive and negative correlations between mean SaO<jats:sub>2<\/jats:sub> and gain and low frequency interval spectra <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> were found, respectively. Strengthening previous hypothesis related to brainstem chronic hypoxemia phenomena affecting vestibular network, implementation of these data could generate future attentions (i) for screening under physiological conditions postural and vestibular detriments in <jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content> subjects, especially exposed at risk settings, and (ii) among <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> parameters, such as mean SaO<jats:sub>2<\/jats:sub>, to propose further reliable tools in monitoring postural and vestibular decay in these patients demonstrating <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> parameters detriments.<\/jats:p>","DOI":"10.1111\/jsr.12516","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T09:56:47Z","timestamp":1490003807000},"page":"487-494","source":"Crossref","is-referenced-by-count":63,"title":["Integrating postural and vestibular dimensions to depict impairment in moderate\u2010to\u2010severe obstructive sleep apnea syndrome patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Alessandro","family":"Micarelli","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine University of Rome Tor Vergata Rome Italy"},{"name":"Neuroscience Unit Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Neuroscience Unit Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Viziano","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Izzi","sequence":"additional","affiliation":[{"name":"Neuroscience Unit Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Neuroscience Unit Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1075","article-title":"Vestibular compensation: analysis of postural re\u2010arrangement as a control index for unilateral vestibular deficit","volume":"14","author":"Alessandrini M.","year":"2003","journal-title":"NeuroReport"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0965-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5664\/jcsm.27388","article-title":"Neural activation patterns during working memory tasks and OSA disease severity: preliminary findings","volume":"5","author":"Archbold K. 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