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In the current study, mechanical allodynia tests, electroencephalograms, electromyogram recordings and c\u2010Fos expression in neuropathic pain\u2010like model mice of partial sciatic nerve ligation were used to investigate the effect of helicid on neuropathic pain and co\u2010morbid insomnia. Our results showed that helicid at a dose of 100, 200 or 400\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> could increase the mechanical threshold by 2.5\u2010, 2.8\u2010 and 3.1\u2010fold for 3\u00a0h after administration, respectively. Helicid at 200 and 400\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> given at 07:00\u00a0hours increased the amount of non\u2010rapid eye movement sleep in a 3\u2010h period by 1.27\u2010 and 1.35\u2010fold in partial sciatic nerve ligated mice. However, helicid (400\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) given at 21:00\u00a0hours did not change the sleep pattern in normal mice. Immunohistochemical study showed that helicid (400\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) administration could reverse the increase of c\u2010Fos expression in the neurons of the rostral anterior cingulate cortex and tuberomammillary nucleus, and the decrease of c\u2010Fos expression in the ventrolateral preoptic area caused by partial sciatic nerve ligation. These results indicate that helicid is an effective agent for both neuropathic pain and sleep disturbances in partial sciatic nerve ligated mice.<\/jats:p>","DOI":"10.1111\/jsr.12518","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T09:52:38Z","timestamp":1490003558000},"page":"386-393","source":"Crossref","is-referenced-by-count":18,"title":["Helicid alleviates pain and sleep disturbances in a neuropathic pain\u2010like model in mice"],"prefix":"10.1111","volume":"26","author":[{"given":"Meng\u2010Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Jian","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University) Ministry of Education Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Chang","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University) Ministry of Education Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000210945.27052.b3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01456.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.12.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18844"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600451103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.01.038"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.02.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141218998"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.02.001"},{"key":"e_1_2_8_12_1","first-page":"830","article-title":"Study on chemical constituents in seeds of Helicia nilagirica (II)","volume":"30","author":"Liu G. 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