{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:13:34Z","timestamp":1775286814028,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This was a retrospective case\u2013control study in 25 patients with narcolepsy with cataplexy and 75 women in the control group. Patients completed the questionnaire by Maurovich\u2010Horvat <jats:italic>et\u00a0al<\/jats:italic>. (<jats:italic>J. Sleep Res<\/jats:italic>., 2013, 22: 496\u2013512). We personally interviewed 25 patients with narcolepsy with cataplexy using the administered questionnaire regarding conception, pregnancy, delivery, perinatal and breastfeeding periods. Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group. In 16 cases (27.1%), a disease before pregnancy was present compared with eight cases (4.9%) in the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); among them, extrinsic asthma was reported 11 times in the narcolepsy with cataplexy group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). Patients with narcolepsy with cataplexy more often had a single pregnancy compared with controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Gestational diabetes was more frequent in patients with narcolepsy with cataplexy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Induced deliveries were higher in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.009). No differences were found between the groups in terms of duration of pregnancies and complications during and after delivery, as during the puerperium. Neonates from patients had heavier birth weight (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.015). The breastfeeding period was longer in patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Modafinil and methylphenidate were the drugs administered in six pregnancies. No significant differences in depression during pregnancy and during puerperium were found between patients and controls. This is the first case\u2013control study in women with narcolepsy with cataplexy related to pregnancy, delivery, childbirth and puerperium. Data suggest that patients have pregnancy outcomes similar to controls. The prevalence of gestational diabetes was higher in women with narcolepsy with cataplexy. Caesarean sections, complications during delivery and normal perinatal period for infants were similar in both groups. Breastfeeding was longer in patients.<\/jats:p>","DOI":"10.1111\/jsr.12567","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T08:56:41Z","timestamp":1496307401000},"page":"270-274","source":"Crossref","is-referenced-by-count":28,"title":["Narcolepsy with cataplexy and pregnancy: a case\u2013control study"],"prefix":"10.1111","volume":"27","author":[{"given":"Elena","family":"Calvo\u2010Ferrandiz","sequence":"first","affiliation":[{"name":"Sleep and Epilepsy Unit \u2013 Clinical Neurophysiology Service University General Hospital Gregorio Maranon University Complutense of Madrid (UCM) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-4000","authenticated-orcid":false,"given":"Rosa","family":"Peraita\u2010Adrados","sequence":"additional","affiliation":[{"name":"Sleep and Epilepsy Unit \u2013 Clinical Neurophysiology Service University General Hospital Gregorio Maranon University Complutense of Madrid (UCM) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2016.11.008"},{"key":"e_1_2_8_3_1","volume-title":"International Classification of Sleep Disorders, 3rd edn (ICSD\u20103)","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.322"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(01)00552-4"},{"key":"e_1_2_8_6_1","unstructured":"EMA.Assesment report for Modafinil\u2010containing products EMA\/4033872011.http:\/\/www.em.europa.eu\/docs\/enGBdocumentlibrary\/Referralsdocument\/Modafinil_31\/WC500105597.pdf."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13728"},{"key":"e_1_2_8_8_1","volume-title":"Joint Meeting of the Arthritis Advisory Committee (AAC) and Drug Safety and Risk Management (DSaRM) Advisory Committee","author":"FDA","year":"2010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200007000-00001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5664\/jcsm.27357","article-title":"Conception, pregnancy, delivery, and breastfeeding in a narcoleptic patient with cataplexy","volume":"4","author":"Hoque R.","year":"2008","journal-title":"J. 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