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Our objective was to examine the cross\u2010sectional association between kidney function and objectively\u2010estimated habitual sleep duration, quality and timing in a cohort of patients with mild to moderate chronic kidney disease. This study involved two <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> clinical centers of the Chronic Renal Insufficiency Cohort (<jats:styled-content style=\"fixed-case\">CRIC<\/jats:styled-content>) study, including 432 participants in a <jats:styled-content style=\"fixed-case\">CRIC<\/jats:styled-content> ancillary sleep study. Habitual sleep duration, quality and timing were measured using wrist actigraphy for 5\u20137\u00a0days. Validated sleep questionnaires assessed subjective sleep quality, daytime sleepiness and risk of sleep apnea. Kidney function was assessed with the estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration equation, and the urinary protein to creatinine ratio. Lower estimated glomerular filtration rate was associated with shorter sleep duration (\u22121.1\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a01.73\u00a0m<jats:sup>\u22122<\/jats:sup> per hour less sleep, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.03), greater sleep fragmentation (\u22122.6\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a01.73\u00a0m<jats:sup>\u22122<\/jats:sup> per 10% higher fragmentation, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and later timing of sleep (\u22120.9\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> min<jats:sup>\u22121<\/jats:sup>\u00a01.73\u00a0m<jats:sup>\u22122<\/jats:sup> per hour later, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.05). Higher protein to creatinine ratio was also associated with greater sleep fragmentation (approximately 28% higher per 10% higher fragmentation, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Subjective sleep quality, sleepiness and persistent snoring were not associated with estimated glomerular filtration rate or protein to creatinine ratio. Thus, worse objective sleep quality was associated with lower estimated glomerular filtration rate and higher protein to creatinine ratio. Shorter sleep duration and later sleep timing were also associated with lower estimated glomerular filtration rate. Physicians treating patients with chronic kidney disease should consider inquiring about sleep and possibly sending for clinical sleep assessment. Longitudinal and interventional trials are needed to understand causal direction.<\/jats:p>","DOI":"10.1111\/jsr.12573","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:15:18Z","timestamp":1498205718000},"page":"283-291","source":"Crossref","is-referenced-by-count":39,"title":["Habitual sleep and kidney function in chronic kidney disease: the Chronic Renal Insufficiency Cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-6168","authenticated-orcid":false,"given":"Kristen L.","family":"Knutson","sequence":"first","affiliation":[{"name":"Department of Neurology Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lash","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Illinois Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Ricardo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Illinois Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Herdegen","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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