{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:23:33Z","timestamp":1740126213100,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CZ.1.05\/1.1.00\/02.0123"],"award-info":[{"award-number":["CZ.1.05\/1.1.00\/02.0123"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["04\u201050103Z"],"award-info":[{"award-number":["04\u201050103Z"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL71478"],"award-info":[{"award-number":["HL71478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1ULIRR024150"],"award-info":[{"award-number":["1ULIRR024150"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Low leptin concentration has been shown to be associated with central sleep apnea in heart failure patients. We hypothesized that low leptin concentration predicts central sleep apnea. Consecutive ambulatory New York Heart Association (<jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>) classes I\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> heart failure patients were studied prospectively, including measurement of serum leptin, echocardiography and polysomnography. Sleep apnea was defined by\u00a0type (central\/mixed\/obstructive) and by apnea\u2013hypopnea index \u22655 by polysomnography. Subjects were divided into four groups by polysomnography: (1) central sleep apnea, (2) mixed apnea, (3) no apnea and (4) obstructive sleep apnea. Fifty\u2010six subjects were included. Eighteen subjects were diagnosed with central sleep apnea, 15 with mixed apnea, 12 with obstructive apnea and 11 with no sleep apnea. Leptin concentration was significantly lower in central sleep apnea compared to obstructive apnea (8\u00a0\u00b1\u00a010.7\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> versus 19.7\u00a0\u00b1\u00a014.7\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P\u00a0<\/jats:italic>\u02c2\u00a00.01) or no sleep apnea (8\u00a0\u00b1\u00a010.7\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> versus 17.1\u00a0\u00b1\u00a08.4\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P\u00a0<\/jats:italic>\u02c2\u00a00.01). Logistic regression showed leptin to be associated independently with central sleep apnea [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 0.19; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 0.06\u20130.62; area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>): 0.80, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01]. For the detection of central sleep apnea, a cut\u2010off value for leptin concentration 5\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> yielded a sensitivity of 50% and specificity of 89%. In conclusion, a low leptin concentration may have utility for the screening of heart failure patients for central sleep apnea.<\/jats:p>","DOI":"10.1111\/jsr.12574","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:15:58Z","timestamp":1498205758000},"page":"240-243","source":"Crossref","is-referenced-by-count":4,"title":["Low leptin concentration may identify heart failure patients with central sleep apnea"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-8021","authenticated-orcid":false,"suffix":"Jr","given":"Ivan","family":"Cundrle","sequence":"first","affiliation":[{"name":"International Clinical Research Center and Department of Anesthesiology and Intensive Care St. Anne's University Hospital Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-1305","authenticated-orcid":false,"given":"Lyle J.","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.683482"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.09.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2472"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1667"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2914"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00154-0"},{"volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specifications","year":"2007","author":"Iber C.","key":"e_1_2_8_9_1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.05.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv624"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.4.1121"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1507"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9903020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00598.2009"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T03:07:25Z","timestamp":1719976045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jsr.12574"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12574","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"type":"print","value":"0962-1105"},{"type":"electronic","value":"1365-2869"}],"subject":[],"published":{"date-parts":[[2017,6,23]]}}}