{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:01:36Z","timestamp":1792116096534,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Experimental and clinical evidence suggests an association between neuroplasticity, brain\u2010derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain\u2010derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain\u2010derived neurotrophic factor concentrations were measured in patients and controls. In patients, blood sampling was followed by polysomnographic sleep investigation. Low brain\u2010derived neurotrophic factor levels were associated with a low percentage of sleep stage N3 and rapid eye movement sleep across diagnostic entities. However, there was no difference in brain\u2010derived neurotrophic factor levels between diagnostic groups. Our data indicate that serum levels of brain\u2010derived neurotrophic factor, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> sleep. This preliminary observation is in accordance with the assumption that sleep stage N3 is involved in the regulation of neuroplasticity.<\/jats:p>","DOI":"10.1111\/jsr.12577","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T06:42:37Z","timestamp":1498632157000},"page":"73-77","source":"Crossref","is-referenced-by-count":52,"title":["Serum brain\u2010derived neurotrophic factor (<scp>BDNF<\/scp>) in sleep\u2010disordered patients: relation to sleep stage N3 and rapid eye movement (<scp>REM<\/scp>) sleep across diagnostic entities"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-1137","authenticated-orcid":false,"given":"Michael","family":"Deuschle","sequence":"first","affiliation":[{"name":"Central Institute of Mental Health Department of Psychiatry and Psychotherapy Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schredl","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health Department of Psychiatry and Psychotherapy Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wisch","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health Department of Psychiatry and Psychotherapy Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schilling","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health Department of Psychiatry and Psychotherapy Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gilles","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health Department of Psychiatry and Psychotherapy Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Geisel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hellweg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"335","article-title":"The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency\u2010 and state\u2010specificity","volume":"35","author":"Bachmann V.","year":"2012","journal-title":"Sleep"},{"key":"e_1_2_8_3_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Berry R. B.","year":"2015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009309"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319946"},{"key":"e_1_2_8_6_1","first-page":"54","article-title":"Changes of serum concentrations of brain\u2010derived neurotrophic factor (BDNF) during treatment with venlafaxine and mirtazapine: role of medication and response to treatment","volume":"46","author":"Deuschle M.","year":"2013","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000545"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.12.1617"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5510-07.2008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076050"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.10"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23380"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2606"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004594"},{"key":"e_1_2_8_16_1","first-page":"335","article-title":"The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency\u2010 and state\u2010specificity","volume":"35","author":"Klein C.","year":"2012","journal-title":"Sleep"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.03.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.11.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.80"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2934"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.98"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2828"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(01)00090-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2015.1131327"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02708-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.025"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.06.011"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T23:53:15Z","timestamp":1695858795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jsr.12577"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12577","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]}}}