{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:40:29Z","timestamp":1780422029858,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T00:00:00Z","timestamp":1519516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy and tolerability of open\u2010label lacosamide in patients with refractory sleep\u2010related hypermotor epilepsy. The study was a case review of eight patients with refractory sleep\u2010related hypermotor epilepsy treated with lacosamide. Seizure diaries compared the mean baseline seizure frequency with the most recent 3\u00a0months of follow\u2010up. Five (62.5%) patients were responders, defined as \u226550% reduction in seizure frequency, over a mean duration of exposure of 21.5\u00a0months. The mean maintenance dose of lacosamide was 400\u00a0mg\/day. No\u2010one reported worsening of seizures. Lacosamide was well tolerated with initial fatigue being the main side\u2010effect. Lacosamide is a potentially efficacious adjunctive therapy in patients with refractory sleep\u2010related hypermotor epilepsy. A double\u2010blind placebo\u2010controlled study would determine its efficacy.<\/jats:p>","DOI":"10.1111\/jsr.12669","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:00:32Z","timestamp":1519624832000},"source":"Crossref","is-referenced-by-count":10,"title":["A case series of lacosamide as adjunctive therapy in refractory sleep\u2010related hypermotor epilepsy (previously nocturnal frontal lobe epilepsy)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-1208","authenticated-orcid":false,"given":"Shanika R.","family":"Samarasekera","sequence":"first","affiliation":[{"name":"Epilepsy Research Centre Department of Medicine University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel F.","family":"Berkovic","sequence":"additional","affiliation":[{"name":"Epilepsy Research Centre Department of Medicine University of Melbourne Melbourne Vic. 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