{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:17:29Z","timestamp":1789003049586,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (<jats:italic>n<\/jats:italic>\u00a0=\u00a01,415, 77% male, age 54\u00a0\u00b1\u00a011 [mean\u00a0\u00b1\u00a0<jats:italic><jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content><\/jats:italic>] years, body mass index 31.7\u00a0\u00b1\u00a06.4\u00a0kg\/m<jats:sup>2<\/jats:sup>, apnea\u2013hypopnea index 37\u00a0\u00b1\u00a024\u00a0<jats:italic>n<\/jats:italic> per hr, Epworth Sleepiness Scale 10.2\u00a0\u00b1\u00a05.0) were selected. Changes in body mass index and neck\/waist\/hip circumferences at baseline and at follow\u2010up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, \u22120.1 to 0.2]\u00a0kg\/m<jats:sup>2<\/jats:sup>) and neck circumference (0.0 (95% confidence interval, \u22120.1 to 0.1]\u00a0cm) were unchanged after positive airway pressure treatment compared with baseline (follow\u2010up duration 1.1\u00a0\u00b1\u00a01.0\u00a0years and compliance 5.2\u00a0\u00b1\u00a02.1\u00a0hr per day). However, in non\u2010obese (body mass index &lt;30\u00a0kg\/m<jats:sup>2<\/jats:sup>) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3\u20130.5]\u00a0kg\/m<jats:sup>2<\/jats:sup> and 0.8 [0.4\u20131.2]\u00a0cm, respectively, all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (\u22120.3 [\u22120.5 to \u22120.1]\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive sleep apnea receiving positive airway pressure treatment.<\/jats:p>","DOI":"10.1111\/jsr.12705","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T06:09:09Z","timestamp":1527228549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the <scp>ESADA<\/scp> cohort"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-6611","authenticated-orcid":false,"given":"Ozen K.","family":"Basoglu","sequence":"first","affiliation":[{"name":"Department of Chest Diseases Ege University Izmir 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College Dublin, School of Medicine Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Verbraecken","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Disorders Centre Antwerp University Hospital and University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Escourrou","sequence":"additional","affiliation":[{"name":"Service d\u00c9xplorations Fonctionnelles Multidisciplinaires Hospital Antoine Beclere Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Antalainen","sequence":"additional","affiliation":[{"name":"Division of Medicine Department of Pulmonary Diseases Turku University Hospital and Sleep Research Centre Department of Pulmonary Diseases and Clinical Allergology, University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kvamme","sequence":"additional","affiliation":[{"name":"Sleep Laboratory, ENT Department F\u00f8rde Central Hospital F\u00f8rde Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-7796","authenticated-orcid":false,"given":"Maria R.","family":"Bonsignore","sequence":"additional","affiliation":[{"name":"Biomedical Department of Internal and Specialistic Medicine (DiBiMIS) Section\u00a0of Pneumology University of Palermo and CNR Institute of Biomedicine and Molecular Immunology Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Schiza","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Sleep Disorders Center University of Crete Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1682","authenticated-orcid":false,"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[{"name":"Center for Sleep and Vigilance Disorders Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Sleep Disorders Center, Respiratory Medicine Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ESADA Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.02.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5664\/jcsm.3686","article-title":"Impact of CPAP on activity patterns and diet in patients with obstructive sleep apnea 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