{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:00:04Z","timestamp":1792087204112,"version":"4.4.0"},"reference-count":170,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL110952"],"award-info":[{"award-number":["T32 HL110952"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Sleep reactivity is the trait\u2010like degree to which stress exposure disrupts sleep, resulting in difficulty falling and staying asleep. Individuals with highly reactive sleep systems experience drastic deterioration of sleep when stressed, whereas those with low sleep reactivity proceed largely unperturbed during stress. Research shows that genetics, familial history of insomnia, female gender and environmental stress influence how the sleep system responds to stress. Further work has identified neurobiological underpinnings for sleep reactivity involving disrupted cortical networks and dysregulation in the autonomic nervous system and hypothalamic\u2010pituitary\u2010adrenal axis. Sleep reactivity is most pathologically and clinically pertinent when in excess, such that high sleep reactivity predicts risk for future insomnia disorder, with early evidence suggesting high sleep reactivity corresponds to severe insomnia phenotypes (sleep onset insomnia and short sleep insomnia). High sleep reactivity is also linked to risk of shift\u2010work disorder, depression and anxiety. Importantly, stress\u2010related worry and rumination may exploit sensitive sleep systems, thereby augmenting the pathogenicity of sleep reactivity. With the development of cost\u2010effective assessment of sleep reactivity, we can now identify individuals at risk of future insomnia, shift\u2010work disorder and mental illness, thus identifying a target population for preventive intervention. Given that insomniacs with high sleep reactivity tend to present with severe insomnia phenotypes, patient sleep reactivity may inform triaging to different levels of treatment. Future research on sleep reactivity is needed to clarify its neurobiology, characterize its long\u2010term prospective associations with insomnia and shift\u2010work disorder phenotypes, and establish its prognostic value for mental illness and other non\u2010sleep disorders.<\/jats:p>","DOI":"10.1111\/jsr.12710","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T02:09:32Z","timestamp":1527214172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":561,"title":["The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders"],"prefix":"10.1111","volume":"27","author":[{"given":"David A.","family":"Kalmbach","sequence":"first","affiliation":[{"name":"Sleep Disorders and Research Center Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-7107","authenticated-orcid":false,"given":"Jason R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Kent State University Kent Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Drake","sequence":"additional","affiliation":[{"name":"Sleep Disorders and Research Center Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","article-title":"Clinical guideline for the evaluation, management and long\u2010term care of obstructive sleep apnea in adults","volume":"5","author":"Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine","year":"2009","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2007.07.010"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2009.03.001"},{"key":"e_1_2_17_5_1","article-title":"International classification of sleep disorders\u2014third edition (ICSD\u20103)","author":"American Academy of Sleep Medicine","year":"2014","journal-title":"AASM Resource Library [Online]"},{"key":"e_1_2_17_6_1","volume-title":"Diagnostic and statistical manual\u2010text revision (DSM\u2010IV\u2010TRim, 2000)","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.4.413"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.01.011"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.10.007"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4240"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.2.217"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2007.04.002"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00182.x"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15402010bsm0201_5"},{"key":"e_1_2_17_15_1","article-title":"Insomnia patients with objective short sleep duration have a blunted response to cognitive behavioral therapy for insomnia","volume":"40","author":"Bathgate C. 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