{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:41:25Z","timestamp":1765827685926,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Periodic limb movements during sleep present with repetitive movements, typically in the lower limbs, during sleep. Periodic limb movements during sleep have been proposed to be associated with increased risk of heart diseases. The aim of this study was to examine the co\u2010morbidity rates of heart disease, including acute myocardial infarction, coronary artery disease and cardiovascular disease, in subjects with or without periodic limb movements during sleep through a meta\u2010analysis. An electronic review of PubMed, Embase, ScienceDirect, Cochrane Library, ProQuest, Web of Science, ClinicalKey and ClinicalTrials.gov was performed. Clinical studies, case\u2010controlled trials and cohort studies were all included in the search. Case reports or series, and non\u2010clinical studies were excluded. A meta\u2010analysis of the results of six studies comparing the prevalence of coronary artery disease\/acute myocardial infarction\/cardiovascular disease in subjects with\/without periodic limb movements during sleep was performed. There were significantly higher co\u2010morbidity rates of coronary artery disease (odds ratio\u00a0=\u00a01.568, 95% confidence interval: 1.187\u20132.073, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and cardiovascular disease (odds ratio\u00a0=\u00a01.279, 95% confidence interval: 1.095\u20131.494, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), but not acute myocardial infarction (odds ratio\u00a0=\u00a01.272, 95% confidence interval\u00a0=\u00a00.942\u20131.718, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.117), in the periodic limb movements during sleep group than in the non\u2010periodic limb movements during sleep group. This meta\u2010analysis highlights the importance of a significantly high prevalence of coronary artery disease and cardiovascular disease in subjects with periodic limb movements during sleep. Further studies should be focused on the potential pathophysiology, and whether treatment for periodic limb movements during sleep can improve the outcome of heart disease.<\/jats:p>","DOI":"10.1111\/jsr.12720","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T07:33:32Z","timestamp":1530171212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Periodic limb movements during sleep are associated with cardiovascular diseases: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Tien\u2010Chi","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Tao","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tsyr\u2010Huey Mental Hospital, Kaohsiung Jen\u2010Ai\u2019s Home Kaohsiung Taiwan"},{"name":"WinShine Clinics in Specialty of Psychiatry Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Ni","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Physiotherapy Department South London and Maudsley NHS Foundation Trust London UK"},{"name":"Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience (IoPPN) King\u2019s College London London UK"},{"name":"Faculty of Health, Social Care and Education Anglia Ruskin University Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto ON Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH) Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao\u2010Yen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Prospect Clinic for Otorhinolaryngology &amp; Neurology Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center Taipei Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-5944","authenticated-orcid":false,"given":"Chung\u2010Yao","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21607"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1986"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(01)00069-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4576"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5484"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2004.03.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00832.2009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5664\/jcsm.2412","article-title":"Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome","volume":"9","author":"Giannaki C. D.","year":"2013","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.6.1497"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2015.11.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.12.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00956.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.08.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.03.018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.02.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.300"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.02.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.05.006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_26_1","first-page":"15","article-title":"Assessing the influence of a single study in meta\u2010analysis","volume":"47","author":"Tobias A.","year":"1999","journal-title":"Stata Technical Bulletin"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.06.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00276-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20257"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx023"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000231513.23919.a1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12314"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.04.060"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.09.037"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210431"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.12720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T12:05:21Z","timestamp":1694347521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jsr.12720"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12720","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"type":"print","value":"0962-1105"},{"type":"electronic","value":"1365-2869"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"2018-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12720"}}