{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:56:31Z","timestamp":1793040991135,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["16-07879S"],"award-info":[{"award-number":["16-07879S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GACR 16-07879S"],"award-info":[{"award-number":["GACR 16-07879S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormalities of eye movements have been reported in patients with Parkinson's disease (PD). However, it is unclear if they occur in the prodromal stage of synucleinopathy represented by idiopathic rapid eye movement sleep behaviour disorder (iRBD). We thus aimed to study eye movements in subjects with iRBD and in de novo PD, to assess if their abnormalities may serve as a clinical biomarker of neurodegeneration. Fifty subjects with polysomnography\u2010confirmed iRBD (46 male, age 40\u201379\u00a0years), 18 newly diagnosed, untreated PD patients (13 male, age 43\u201375\u00a0years) and 25 healthy controls (20 male, age 42\u201379\u00a0years) were prospectively enrolled. Horizontal and vertical ocular prosaccades and antisaccades were investigated with video\u2010oculography. All patients completed the MDS\u2010UPDRS and the Montreal Cognitive Assessment. In addition, a neuropsychological battery was performed on iRBD subjects. When compared with healthy controls, both de novo PD patients and iRBD subjects showed increased error rates in the horizontal antisaccade task (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05 respectively). In the iRBD group, the error rates in horizontal and vertical antisaccades correlated with performances in the Prague Stroop Test and the Grooved Pegboard Test, as well as with motor scores of the MDS\u2010UPDRS. De novo PD patients showed a lower gain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) compared with controls. In conclusion, the increased error rate in the antisaccade task of iRBD and PD patients reflects a dysfunction of the dorsolateral prefrontal cortex and is related to the impairment of executive functions and attention.<\/jats:p>","DOI":"10.1111\/jsr.12742","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:54:50Z","timestamp":1532566490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Eye movements in idiopathic rapid eye movement sleep behaviour disorder: High antisaccade error rate reflects prefrontal cortex dysfunction"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-338X","authenticated-orcid":false,"given":"Jarom\u00edr","family":"Hanu\u0161ka","sequence":"first","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"},{"name":"Department of Neurosurgery Na Homolce Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rusz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"},{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Bezdicek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ulmanov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"},{"name":"AP HP, Neurology Department Piti\u00e9 Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Du\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"},{"name":"Department of Radiology Charles University, 1st Faculty of Medicine and General University Hospital Prague Czech 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