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The efficacy of suvorexant was established in Phase 2\u20133 trials with treatment durations ranging from 1 to 12\u2005months in patients with insomnia. Suvorexant is effective at improving sleep assessed by patient self\u2010report and by polysomnography, with generally little effect on underlying sleep architecture. The main side\u2010effect is next day somnolence. With the growing realization of the important connections between sleep and other disorders, studies are ongoing to explore this novel mechanism in other disorders such as Alzheimer's disease and depression.<\/jats:p>","DOI":"10.1111\/jsr.12782","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T23:03:42Z","timestamp":1539903822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-031X","authenticated-orcid":false,"given":"W. Joseph","family":"Herring","sequence":"first","affiliation":[{"name":"Clinical Research Merck &amp; Co., Inc. 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