{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:25:53Z","timestamp":1782303953564,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Neuropsychiatric aspects of neurodegenerative disorders","award":["PROGRES Q27\/LF1"],"award-info":[{"award-number":["PROGRES Q27\/LF1"]}]},{"name":"First Faculty of Medicine Charles University Prague"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Narcolepsy with cataplexy is a lifelong disease resulting from the loss of hypocretin neurons in the hypothalamus; structural changes are not, however, limited only to the hypothalamus. We previously revealed an overall hippocampal volume loss in n<jats:styled-content style=\"fixed-case\">arcolepsy with cataplexy<\/jats:styled-content>. The aim of this study is to describe the volume reduction of the anterior and posterior parts of the hippocampus in patients with n<jats:styled-content style=\"fixed-case\">arcolepsy with cataplexy<\/jats:styled-content>in comparison with a control group. The anterior hippocampus is more involved in episodic memory and imagination, and the posterior hippocampus in spatial memory. Manual magnetic resonance imaging hippocampal volumetry was performed in 48 patients with n<jats:styled-content style=\"fixed-case\">arcolepsy with cataplexy<\/jats:styled-content>and in 37 controls using the manual delineation technique in the ScanView program. All participants were examined on the same 1.5 T<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>scanner; measurement was carried out as T1W 3D image with a slice thickness of 1.0\/0\u2005mm. There was a significant absolute loss of the total volume of the anterior hippocampus (sum of left and right) in patients with n<jats:styled-content style=\"fixed-case\">arcolepsy with cataplexy<\/jats:styled-content>as compared with the controls (10.5%,<jats:italic>p\u2005<\/jats:italic>=\u2005.03<jats:styled-content style=\"fixed-case\">ANCOVA<\/jats:styled-content>after correcting for total brain volume and multiple testing). We found a negative correlation between the total anterior hippocampus volume and the duration of the disease (<jats:italic>R\u2005<\/jats:italic>=\u2005\u22120.4036,<jats:italic>p\u2005<\/jats:italic>=\u2005.016\u2014corrected for multiple testing).<\/jats:p>","DOI":"10.1111\/jsr.12785","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T08:06:13Z","timestamp":1542096373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Anterior hippocampus volume loss in narcolepsy with cataplexy"],"prefix":"10.1111","volume":"28","author":[{"given":"Martina","family":"K\u0159e\u010dkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Anatomy Charles University, First Faculty of Medicine Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kemlink","sequence":"additional","affiliation":[{"name":"Department of Neurology and 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