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In an effort to identify potential sleep disturbances in a small animal model, we used a previously reported <jats:italic>Nf1<\/jats:italic> conditional knockout (<jats:italic>Nf1<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sup>CKO<\/jats:sup><\/jats:styled-content>) mouse strain. In contrast to <jats:italic>Nf1<\/jats:italic> mutant flies, the distribution of vigilance states was intact in <jats:italic>Nf1<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sup>CKO<\/jats:sup><\/jats:styled-content> mice. However, <jats:italic>Nf1<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sup>CKO<\/jats:sup><\/jats:styled-content> mice exhibited increased non\u2010<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> sleep (<jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content>)\u2010to\u2010wake and wake\u2010to\u2010<jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content> transitions. This sleep disruption was accompanied by decreased bout durations during awake and <jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content> sleep states under both light and dark conditions. Moreover, <jats:italic>Nf1<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sup>CKO<\/jats:sup><\/jats:styled-content> mice have higher percentage delta power during awake and <jats:styled-content style=\"fixed-case\">NREM<\/jats:styled-content> sleep states under all light conditions. Taken together, <jats:italic>Nf1<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sup>CKO<\/jats:sup><\/jats:styled-content> mice phenocopy some of the sleep disturbances observed in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients and provide a tractable platform to explore the molecular mechanisms governing sleep abnormalities in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/jsr.12816","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T18:41:59Z","timestamp":1546627319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neurofibromatosis type 1 (<i>Nf1<\/i>)\u2010mutant mice exhibit increased sleep fragmentation"],"prefix":"10.1111","volume":"28","author":[{"given":"Corina","family":"Anastasaki","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University 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