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However, these studies were mainly performed during the asymptomatic period and therefore their findings might not apply to changes in sensory processing that occur during the symptomatic period. The objective of this study was to investigate the function of sensory nerve fibres in <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> patients using the current perception threshold (<jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>) test during the daytime and in the presence of symptoms. Ninety\u2010three patients with <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> and 34 healthy controls were included in the study. <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> patients were further divided into two subgroups, those who were experiencing <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> symptoms during the <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> test (symptom+) and those without symptoms (symptom\u2212). Demographic data, <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> rating scale score and visual analogue scale were collected. Of the 127 enrolled subjects, <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> values were significantly lower in <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> patients than in controls for all three frequencies. Among the control and <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> subgroups (53 symptom+, 40 symptom\u2212), symptom+ patients showed lower <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> values than controls. This finding indicates a relative hyperaesthetic state in the sensory afferents of peripheral nerves in symptom+ patients. There were no significant differences between the symptom\u2212 group and controls. The significantly lower <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> values for all three frequencies in symptom+ patients suggest that central sensory processing disturbance of sensory nerve fibres\u2019 input may be involved in the development of symptoms in <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/jsr.12890","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T21:20:54Z","timestamp":1561497654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Symptom\u2010related changes in current perception threshold of restless legs syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-5355","authenticated-orcid":false,"given":"Hung Youl","family":"Seok","sequence":"first","affiliation":[{"name":"Department of Neurology Dongsan Medical Center School of Medicine Keimyung University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Neurology Dongsan Medical Center School of Medicine Keimyung University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-5236","authenticated-orcid":false,"given":"Gholam K.","family":"Motamedi","sequence":"additional","affiliation":[{"name":"Department of Neurology Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-1045","authenticated-orcid":false,"given":"Yong Won","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology Dongsan Medical Center School of Medicine Keimyung University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.03.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199904)22:4<523::AID-MUS16>3.0.CO;2-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq026"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.03.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.024"},{"key":"e_1_2_9_8_1","first-page":"449","article-title":"Measurement of current perception thresholds using the Neurometer((R)) \u2013 Applicability in diabetic neuropathy","volume":"88","author":"Inceu G. 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