{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:32:48Z","timestamp":1770777168488,"version":"3.50.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Research Priority Program of the University of Zurich \u2018\u2018Sleep and Health\u2019\u2019"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320030_153387,"],"award-info":[{"award-number":["320030_153387,"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320030_179443"],"award-info":[{"award-number":["320030_179443"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synaptic downscaling during sleep, a physiological process to restore synaptic homeostasis and maintain learning efficiency and healthy brain development, has been related to a reduction of the slope of sleep slow waves (SSW). However, such synaptic downscaling seems not to be reflected in high\u2010amplitude SSW. Recently we have shown reduced SSW slopes during hormonal treatment (adrenocorticotrophic hormone, prednisolone) in patients with West syndrome (WS). Yet, whether this reduction was related to successful treatment or reflects a specific effect of hormone therapy is unknown. Thus, we retrospectively analysed nap electroencephalograms of 61 patients with WS successfully treated with hormones, vigabatrin (VGB), or both. The slope of SSW during treatment (T1) and 2\u20137\u00a0months later (T2) when hormonal treatment was tapered off were compared between the treatment groups and healthy, age\u2010matched controls. At T1 hormone treatment reduced the slope of low\u2010amplitude SSW, whereas VGB increased the slope of high\u2010amplitude SSW (linear mixed effect model: <jats:italic>F<\/jats:italic><jats:sub>Group<\/jats:sub>\u00a0=\u00a07.04, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>F<\/jats:italic><jats:sub>Amplitude<\/jats:sub>\u00a0=\u00a01,646.68, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>F<\/jats:italic><jats:sub>Group*Amplitude<\/jats:sub>\u00a0=\u00a03.38, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). At T2, untreated patients did not differ anymore from healthy controls, whereas those still under VGB showed the same alterations as those with VGB at T1. This result indicates a disparate effect of VGB and hormone on the SSW slope. In particular, hormones seem to reduce the slope of cortical generated low\u2010amplitude SSW, similar to the physiological synaptic downscaling during sleep. Thus, a loss of functional neuronal connectivity might be an alternative explanation of the antiepileptic effect of hormonal treatment.<\/jats:p>","DOI":"10.1111\/jsr.13137","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T11:55:56Z","timestamp":1594641356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disparate effects of hormones and vigabatrin on sleep slow waves in patients with West syndrome \u2013 An indication of their mode of action?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-5835","authenticated-orcid":false,"given":"Bianka","family":"Heinrich","sequence":"first","affiliation":[{"name":"Department of Neuropediatrics University Children\u2019s Hospital Zurich Z\u00fcrich 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Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Critelli","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Pediatric Sleep Disorders Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-9466","authenticated-orcid":false,"given":"Reto","family":"Huber","sequence":"additional","affiliation":[{"name":"Pediatric Sleep Disorders Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Children\u2019s Research Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Child Development Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital University of Zurich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-8598","authenticated-orcid":false,"given":"Sara","family":"Fattinger","sequence":"additional","affiliation":[{"name":"Pediatric Sleep Disorders Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Children\u2019s Research Center University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"},{"name":"Child Development Center University Children\u2019s Hospital Zurich Z\u00fcrich 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