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Data from two 12\u2010week randomized controlled trials of solriamfetol were analyzed. Participants completed the Epworth Sleepiness Scale, 10\u2010item Functional Outcomes of Sleep Questionnaire, Work Productivity and Activity Impairment questionnaire and 36\u2010Item Short Form Health Survey and performed the Maintenance of Wakefulness Test at baseline and weeks 4, 8 and 12. Patient Global Impression of Change was assessed at weeks 4, 8 and 12. Pearson correlations were calculated for change in scores from baseline to week 12. For both studies, changes in the 10\u2010item Functional Outcomes of Sleep Questionnaire were highly correlated (absolute value &gt;0.5) with changes in Epworth Sleepiness Scale scores; changes in multiple domain scores of the 36\u2010Item Short Form Health Survey and Work Productivity and Activity Impairment questionnaire were moderately correlated (0.3\u20130.5) with changes in Epworth Sleepiness Scale scores in both studies and highly correlated for participants with narcolepsy. Changes in Maintenance of Wakefulness Test scores correlated moderately with changes in Epworth Sleepiness Scale scores in both studies. At week 12, Patient Global Impression of Change ratings correlated highly with Epworth Sleepiness Scale and 10\u2010item Functional Outcomes of Sleep Questionnaire scores for both disorders. Other correlations were low. Self\u2010reported assessments of sleepiness and global improvement appear to be more strongly correlated with measures of functioning and health\u2010related quality of life than objectively assessed sleepiness.<\/jats:p>","DOI":"10.1111\/jsr.13210","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:21:13Z","timestamp":1602634873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Relationship between sleep efficacy endpoints and measures of functional status and health\u2010related quality of life in participants with narcolepsy or obstructive sleep apnea treated for excessive daytime sleepiness"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-5766","authenticated-orcid":false,"given":"Terri E.","family":"Weaver","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Nursing Science Center for Sleep and Health Research College of Nursing; Division of Pulmonary, Critical Care, Sleep &amp; Allergy, Department of Medicine, College of Medicine University of Illinois at Chicago Chicago IL USA"},{"name":"Division of Pulmonary, Critical Care, Sleep &amp; Allergy Department of Medicine College of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Mathias","sequence":"additional","affiliation":[{"name":"Health Outcomes Solutions Winter Park FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Crosby","sequence":"additional","affiliation":[{"name":"Health Outcomes Solutions Winter Park FL USA"},{"name":"Sanford Center for Bio\u2010Behavioral Research Fargo ND USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Bron","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Bujanover","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Menno","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen F.","family":"Villa","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Drake","sequence":"additional","affiliation":[{"name":"Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2018.18.02.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.10.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01473.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4262"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0076-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-016-0053-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.7.915"},{"key":"e_1_2_9_9_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.1.123"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27497"},{"key":"e_1_2_9_12_1","volume-title":"EQ\u20105D\u20105L user guide","author":"EuroQol Research Foundation","year":"2019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4488"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0579.2003.00208.x"},{"key":"e_1_2_9_16_1","first-page":"325","volume-title":"Measuring functioning and well\u2010being: The Medical Outcomes Study approach","author":"Hays R. 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