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The present pilot study explored associations between OSA severity and metabolites in women with GDM. A total of 81 obese women with diet\u2010controlled GDM had OSA assessment (median gestational age [GA] 29\u00a0weeks). The metabolic profile was assayed from fasting serum samples via liquid chromatography\u2013mass spectrometry (LC\u2010MS) using an untargeted approach. Metabolites were extracted and subjected to an Agilent 1,290 UPLC coupled to an Agilent 6,545 quadrupole time\u2010of\u2010flight (Q\u2010TOF) MS. Data were acquired using electrospray ionisation in positive and negative ion modes. The raw LC\u2010MS data were processed using the OpenMS toolkit to detect and quantify features, and these features were annotated using the Human Metabolite Database. The feature data were compared with OSA status, apnea\u2013hypopnea index (AHI), body mass index (BMI) and GA using \u201climma\u201d in R. Correlation analyses of the continuous covariates were performed using Kendall\u2019s Tau test. The<jats:italic>p<\/jats:italic>values were adjusted for multiple testing using the Benjamini\u2013Hochberg false discovery rate correction. A total of 42 women (51.8%) had OSA, with a median AHI of 9.1\u00a0events\/hr. There were no significant differences in metabolomics profiles between those with and without OSA. However, differential analyses modelling in GA and BMI found 12 features that significantly associated with the AHI. These features could be annotated to oestradiols, lysophospholipids, and fatty acids, with higher levels related to higher AHI. Metabolites including oestradiols and phospholipids may be involved in pathogenesis of OSA in pregnant women with GDM. A targeted approach may help elucidate our understanding of their role in OSA in this population.<\/jats:p>","DOI":"10.1111\/jsr.13327","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T07:07:55Z","timestamp":1617260875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Metabolomic profile associated with obstructive sleep apnoea severity in obese pregnant women with gestational diabetes mellitus: A pilot study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-1069","authenticated-orcid":false,"given":"Sirimon","family":"Reutrakul","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Mass 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