{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:15:11Z","timestamp":1787170511377,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009543","name":"Pontificia Universidad Javeriana","doi-asserted-by":"publisher","award":["8394"],"award-info":[{"award-number":["8394"]}],"id":[{"id":"10.13039\/501100009543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnea syndrome affects 1%\u20134% of all children worldwide. Currently, diagnosis of obstructive sleep apnea is based on sea\u2010level guidelines, without taking into account the altitude at which the populations live. It has been shown that at 3,200 m of altitude there is an increase in obstructive events in healthy children aged 7 to 16\u00a0years; on the other hand, it is known that SpO\n                    <jats:sub>2<\/jats:sub>\n                    dispersion between individuals becomes wider as altitude increases, a phenomenon that is more marked during sleep. About 17 million Colombians live in regions between 2,500\u00a0m and 2,700\u00a0m, as do significant populations in other Latin American countries. This research aimed to characterize respiratory polygraphy sleep parameters in healthy, non\u2010snoring children aged 4\u20139\u00a0years living at 2,560 m. We carried out home respiratory polygraphy in 32 children with a mean age of 6.2\u00a0years (range 4\u20139 years). The average recorded sleep time was 7.8\u00a0h, the median apnea\u2013hypopnea index was 9.2\/h, the obstructive apnea\u2013hypopnea index had a median of 8.8\/h (p5 4.2 to p95 17.9) and central apnea a median of 0.4\/h. The median SpO\n                    <jats:sub>2<\/jats:sub>\n                    was 93% (p5 90.5 to p95 94) and transcutaneous CO\n                    <jats:sub>2<\/jats:sub>\n                    had a median of 39.4\u00a0mmHg (p531.7 to p95 42.3). The median oxygen desaturation index\u00a0\u2265\u00a03% was 11.2 and median oxygen desaturation index\u00a0\u2265\u00a04% was 3.9. Normal measurements for respiratory polygraphy obtained at sea level do not apply to children at altitude. If such guidelines are used, obstructive sleep apnea will be over\u2010diagnosed, resulting in unnecessary adenotonsillectomies, among other interventions.\n                  <\/jats:p>","DOI":"10.1111\/jsr.13341","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T01:14:15Z","timestamp":1615857255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Normal values for respiratory sleep polygraphy in children aged 4 to 9 years at 2,560 m above sea level"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-1265","authenticated-orcid":false,"given":"Santiago","family":"Ucros","sequence":"first","affiliation":[{"name":"Pediatrics Department Fundaci\u00f3n Santa Fe de Bogota Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Granados","sequence":"additional","affiliation":[{"name":"Pediatrics Department Pontifical Xavierian University Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Hill","sequence":"additional","affiliation":[{"name":"School of Clinical and Experimental Sciences University of Southampton Hampshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Castro\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Pediatrics Department Pontifical Catholic University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Camilo","family":"Ospina","sequence":"additional","affiliation":[{"name":"ENT Pontifical Xavierian University Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1579-2129(08)60052-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1959"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1305492"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3134"},{"key":"e_1_2_9_8_1","first-page":"1147","article-title":"Obstructive sleep apnea in children","volume":"69","author":"Chan J.","year":"2004","journal-title":"American Family Physician"},{"key":"e_1_2_9_9_1","first-page":"224","article-title":"Update on paediatric obstructive sleep apnoea","volume":"8","author":"Dehlink E.","year":"2016","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-3207"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318613"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.126477"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30416-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.05.039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5740"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6316"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00385-2015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114209"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6772"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00004"},{"key":"e_1_2_9_22_1","first-page":"576","article-title":"Diagnosis and management of childhood obstructive sleep apnea syndrome","volume":"130","author":"Marcus C. 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