{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:11:52Z","timestamp":1784333512296,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013363","name":"Lunge Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Altitude exposure induces hypoxaemia in patients with chronic obstructive pulmonary disease (COPD), particularly during sleep. The present study tested the hypothesis in patients with COPD staying overnight at high altitude that nocturnal arterial hypoxaemia is associated with impaired cerebral tissue oxygenation (CTO). A total of 35 patients with moderate\u2010to\u2010severe COPD, living at &lt;800\u00a0m (mean [<jats:italic>SD<\/jats:italic>] age 62.4\u00a0[12.3]\u00a0years, forced expiratory volume in 1\u00a0s [FEV<jats:sub>1<\/jats:sub>] 61\u00a0[16]% predicted, awake pulse oximetry \u226592%) underwent continuous overnight monitoring of pulse oximetry (oxygen saturation [SpO<jats:sub>2<\/jats:sub>]) and near\u2010infrared spectroscopy of prefrontal CTO, respectively, at 490\u00a0m and 2,590\u00a0m. Regression analysis was used to evaluate whether nocturnal arterial desaturation (COPD<jats:sub>Desat<\/jats:sub>, SpO<jats:sub>2<\/jats:sub> &lt;90% for &gt;30% of night\u2010time) at 490\u00a0m predicted CTO at 2,590\u00a0m when controlling for baseline variables. At 2,590\u00a0m, mean nocturnal SpO<jats:sub>2<\/jats:sub> and CTO were decreased versus 490\u00a0m, mean change \u22128.8% (95% confidence interval [CI] \u221210.0 to \u22127.6) and \u22123.6% (95% CI \u22125.7 to \u22121.6), difference in change \u0394CTO\u2010\u0394SpO<jats:sub>2<\/jats:sub> 5.2% (95% CI 3.0 to 7.3; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Moreover, frequent cyclic desaturations (\u22654% dips\/hr) occurred in SpO<jats:sub>2<\/jats:sub> and CTO, mean change from 490\u00a0m 35.3\/hr (95% CI 24.9 to 45.7) and 3.4\/hr (95% CI 1.4 to 5.3), difference in change \u0394CTO\u2010\u0394SpO<jats:sub>2<\/jats:sub> \u221232.8\/hr (95% CI \u221243.8 to \u221221.8; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Regression analysis confirmed an association of COPD<jats:sub>Desat<\/jats:sub> with lower CTO at 2,590\u00a0m (coefficient \u22127.6%, 95% CI \u221213.2 to \u22122.0; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) when controlling for several confounders. We conclude that lowlanders with COPD staying overnight at 2,590\u00a0m experience altitude\u2010induced hypoxaemia and periodic breathing in association with sustained and intermittent cerebral deoxygenation. Although less pronounced than the arterial deoxygenation, the altitude\u2010induced cerebral tissue deoxygenation may represent a risk of brain dysfunction, especially in patients with COPD with nocturnal hypoxaemia at low altitude.<\/jats:p>","DOI":"10.1111\/jsr.13365","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:39:54Z","timestamp":1619483994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nocturnal cerebral tissue oxygenation in lowlanders with chronic obstructive pulmonary disease travelling to an altitude of 2,590\u00a0m: Data from a randomised trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-5029","authenticated-orcid":false,"given":"Michael","family":"Furian","sequence":"first","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Flueck","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp M.","family":"Scheiwiller","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Mueller\u2010Mottet","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz M.","family":"Urner","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsogyal D.","family":"Latshang","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Pulmonary Division and Sleep Disorders Center University Hospital of Zurich Zurich 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