{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:21:48Z","timestamp":1766427708380,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Excessive daytime sleepiness is a common symptom in obese patients with obstructive sleep apnea. We investigated predisposing factors of excessive daytime sleepiness by comparing obese non\u2010sleepy with sleepy patients with obstructive sleep apnea. Excessive daytime sleepiness was determined by the Epworth Sleepiness Scale in 43 patients (34\u00a0men and 9 women) with obstructive sleep apnea (apnea\u2013hypopnea index \u2265\u00a015 events per hr) and obesity (body mass index\u00a0\u2265\u00a030\u00a0kg\u2005m<jats:sup>\u22122<\/jats:sup>). Two subgroups were formed with (Epworth Sleepiness Scale\u00a0\u2265\u00a011) and without (Epworth Sleepiness Scale\u00a0&lt;\u00a011) excessive daytime sleepiness. The concept of excessive daytime sleepiness was compared with other established daytime performance tests (Stanford Sleepiness Scale, Multiple Sleep Latency Test, Pupillographic Sleepiness Test, Marburger Vigilance test). Associations were calculated between excessive daytime sleepiness and demographic, metabolic and polysomnographic data. We included 19\u00a0sleepy patients (mean Epworth Sleepiness Scale score 15.2) and 24 non\u2010sleepy patients (mean Epworth Sleepiness Scale score 5.8). Epworth Sleepiness Scale was negatively correlated with age and morning cortisol. Epworth Sleepiness Scale was positively correlated with body mass index, Stanford Sleepiness Scale, Beck\u2019s Depression Inventory and Marburger Vigilance test. Sleepy obese patients were significantly younger (mean 49.1\u00a0years), showed lower morning cortisol level (mean 9.41\u00a0\u03bcg\u2005L<jats:sup>\u22121<\/jats:sup>) and a trend to higher body mass index (mean 37.5\u00a0kg\u2005m<jats:sup>\u2212<\/jats:sup>\u00b2) compared with non\u2010sleepy obese patients (mean: 59.3\u00a0years, 5.7\u00a0\u03bcg\u2005L<jats:sup>\u22121<\/jats:sup>, 34.6\u00a0kg\u2005m<jats:sup>\u2212<\/jats:sup>\u00b2, respectively). Many different excessive daytime sleepiness phenotypes are probably enclosed in obese patients with obstructive sleep apnea. Epworth Sleepiness Scale scores were best reflected by the objective Marburger Vigilance test results. The objective test can be particularly useful in cohorts where subjective reports are unreliable and operational readiness is paramount. Sleepy and non\u2010sleepy obese patients with obstructive sleep apnea were similar in all polysomnographic parameters. Sleepy patients were younger, heavier and showed lower morning cortisol levels than non\u2010sleepy patients.<\/jats:p>","DOI":"10.1111\/jsr.13458","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T11:26:06Z","timestamp":1628335566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predisposing factors of daytime sleepiness in obese OSA patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-3836","authenticated-orcid":false,"given":"Regina","family":"Conradt","sequence":"first","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitas","family":"Redhardt","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Beutel","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-3282","authenticated-orcid":false,"given":"Olaf","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Cassel","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Kesper","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Koehler","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulf","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Department of Medical Cell Biology Institute for Anatomy and Cell Biology Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Koehler","sequence":"additional","affiliation":[{"name":"Division of Pneumology Department of Sleep Medicine Internal Medicine University Hospital Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2005.08.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.093740"},{"volume-title":"Manual for the Beck Depression Inventory\u2010II","year":"1996","author":"Beck A. T.","key":"e_1_2_9_4_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20101056"},{"volume-title":"Kompendium Schlafmedizin f\u00fcr Ausbildung","year":"2011","author":"Cassel W.","key":"e_1_2_9_7_1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32834b7e04"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102869.1998.00116.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00126.2007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.297"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00505"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.7.508"},{"key":"e_1_2_9_15_1","first-page":"235","article-title":"Reliability of the stanford sleepiness scale compared to short duration performance tests and the Wilkinson Auditory Vigilance Task","volume":"21","author":"Glenville M.","year":"1978","journal-title":"Advances in Bioscience"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(15)00043\u20100"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102869.2000.00177.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.9.994"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508\u2010014\u20100591\u20108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw033"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.1.113"},{"key":"e_1_2_9_23_1","first-page":"671","article-title":"Computerized analysis of pupillograms in studies of alertness","volume":"33","author":"McLaren J. W.","year":"1992","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.21964"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.12.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.5.565"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13066"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26511"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.6.751"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.05.003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1367.023"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.12.1333"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.12.014"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-054x.2000.00116.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201012\u2010849"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.13458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.13458","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.13458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:37:15Z","timestamp":1692841035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.13458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jsr.13458"],"URL":"https:\/\/doi.org\/10.1111\/jsr.13458","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"type":"print","value":"0962-1105"},{"type":"electronic","value":"1365-2869"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"2021-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13458"}}