{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:46:27Z","timestamp":1770353187877,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/T032529\/1"],"award-info":[{"award-number":["MR\/T032529\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Impairment of the circadian rhythm promotes lung inflammation and fibrosis in pre\u2010clinical models. We aimed to examine whether short and\/or long sleep duration and other markers of sleep\u2013wake patterns are associated with a greater burden of lung parenchymal abnormalities on computed tomography among adults. We cross\u2010sectionally examined associations of sleep duration captured by actigraphy with interstitial lung abnormalities (<jats:italic>n<\/jats:italic>\u00a0=\u00a01111) and high attenuation areas (<jats:italic>n<\/jats:italic>\u00a0=\u00a01416) on computed tomography scan in the Multi\u2010Ethnic Study of Atherosclerosis at Exam 5 (2010\u20132013). We adjusted for potential confounders in logistic and linear regression models for interstitial lung abnormalities and high attenuation area, respectively. High attenuation area models were also adjusted for study site, lung volume imaged, radiation dose and stratified by body mass index. Secondary exposures were self\u2010reported sleep duration, sleep fragmentation index, sleep midpoint and chronotype. The mean age of those with longer sleep duration (\u2265\u20058\u00a0hr) was 70\u00a0years and the prevalence of interstitial lung abnormalities was 14%. Increasing actigraphy\u2010based sleep duration among participants with \u2265\u20058\u00a0hr of sleep was associated with a higher adjusted odds of interstitial lung abnormalities (odds ratio of 2.66 per 1\u2010hr increment, 95% confidence interval 1.42\u20134.99). Longer sleep duration and higher sleep fragmentation index were associated with greater high attenuation area on computed tomography among participants with a body mass index &lt;\u200525\u00a0kg\u2005m<jats:sup>\u22122<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2010value for interaction &lt;\u20050.02). Self\u2010reported sleep duration, later sleep midpoint and evening chronotype were not associated with outcomes. Actigraphy\u2010based longer sleep duration and sleep fragmentation were associated with a greater burden of lung abnormalities on computed tomography scan.<\/jats:p>","DOI":"10.1111\/jsr.13475","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T08:10:42Z","timestamp":1631175042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations of sleep duration and sleep\u2013wake rhythm with lung parenchymal abnormalities on computed tomography: The\u00a0MESA study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-150X","authenticated-orcid":false,"given":"John S.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine University of Virginia School of Medicine  Charlottesville VA USA"},{"name":"Department of Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan S.","family":"Dashti","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine and Department of Anesthesia Critical Care, and Pain Medicine Center for Genomic Medicine Massachusetts General Hospital and Harvard Medical School  Boston MA USA"},{"name":"Program in Medical and Population Genetics Broad Institute  Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian E.","family":"Cade","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics Broad Institute  Cambridge MA USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston MA USA"},{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna J.","family":"Podolanczuk","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Weill Cornell Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"O'Hearn","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia School of Medicine  Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Medicine, and Biomedical Engineering University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics Broad Institute  Cambridge MA USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston MA USA"},{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Blaikley","sequence":"additional","affiliation":[{"name":"Faculty of Biology Medicine and Health The University of Manchester  Manchester UK"},{"name":"Manchester University National Health Service Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Graham","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Irving Medical Center  New York NY USA"},{"name":"Department of Epidemiology Mailman School of Public Health  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"},{"name":"Division of Sleep Medicine Harvard Medical School  Boston MA USA"},{"name":"Division of Pulmonary Critical Care, and Sleep Medicine Beth Israel Deaconess Medical Center  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010020827"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808836"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100441\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4732"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00062\u20102019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912109117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908681"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009\u20100647"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30168\u20105"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2007085"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2014.12.010"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"97","article-title":"A self\u2010assessment questionnaire to determine morningness\u2010eveningness in human circadian rhythms","volume":"4","author":"Horne J. 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