{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:07Z","timestamp":1787015707822,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>There is conflicting evidence regarding the associations between sleep deprivation and inflammatory biomarkers indicative of cardiovascular disease risk, such as high\u2010sensitivity C\u2010reactive protein (hsCRP). The association between sleep habits and hsCRP was quantified in a nationally representative sample of adults in the United States and mediation by ideal cardiovascular health metrics was explored. A cross\u2010sectional analysis of cardiovascular disease\u2010free participants aged 20\u201379\u00a0years from the 2017\u20132018\u00a0National Health and Nutrition Examination Survey was conducted. The primary exposures were self\u2010reported sleep duration, sleep debt (difference between the average weekday and weekend sleep duration), and ideal cardiovascular health (11\u201314 points). The primary outcome was hsCRP (high\u2010risk\u00a0\u2265\u00a03.0\u00a0mg\/L). Multivariable robust Poisson models were used to estimate prevalence ratios after multiple imputation. A subgroup analysis of shift workers was also conducted. Of 4027 participants included (mean age 46\u00a0years; 52% female; 41% shift workers), the prevalence of sleeping &lt;6\u00a0h on weekdays was 9%, with 40% sleeping \u22659\u00a0h on weekends. One\u2010quarter had a high (\u22652\u00a0h) sleep debt, 82% had poor cardiovascular health, and 34% had high\u2010risk hsCRP. There were no significant associations between weekday sleep duration or sleep debt with high\u2010risk hsCRP, even among shift workers. Mediation analysis was not conducted. Ideal cardiovascular health was associated with a lower prevalence of high\u2010risk hsCRP (prevalence ratios, 0.60, 95% CI, 0.48\u20130.75). The lack of significant associations suggests a complex interrelationship of hsCRP with factors beyond sleep duration. Examination of populations at highest risk of chronic sleep deprivation could help to elucidate the association with systemic inflammation\u2010related outcomes.<\/jats:p>","DOI":"10.1111\/jsr.13497","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T06:44:49Z","timestamp":1633329889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between sleep characteristics, ideal cardiovascular health, and systemic inflammation, NHANES 2017\u20132018"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-1014","authenticated-orcid":false,"given":"Rebecca E.","family":"Cash","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remle P.","family":"Crowe","sequence":"additional","affiliation":[{"name":"ESO  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Emergency Medicine Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Patrick","sequence":"additional","affiliation":[{"name":"Montgomery County Hospital District  Conroe Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u00a0Michael","family":"Wells\u2010Whitworth","sequence":"additional","affiliation":[{"name":"Montgomery County Hospital District  Conroe Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Barger","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Sleep and Circadian Disorders Departments of Medicine and Neurology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022\u20103514.51.6.1173"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u20103\u201021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148983.88334.80"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz149"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd17.190424"},{"key":"e_1_2_8_7_1","volume-title":"National Health and Nutrition Examination Survey","author":"Centers for Disease Control and Prevention, and National Center for Health Statistics"},{"issue":"127","key":"e_1_2_8_8_1","first-page":"1","article-title":"Prescription sleep aid use among adults: United States, 2005\u20102010","author":"Chong Y.","year":"2013","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816d83e4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2015.10.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00859.2014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.05.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.08.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.06.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.07.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2019.12.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872617741733"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Mlr.0000093487.78664.3c"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.111571"},{"key":"e_1_2_8_21_1","first-page":"1107","article-title":"Relation of C\u2010relative protein and coronary heart disease in the MRFIT nested case\u2010control study. 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