{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:23:56Z","timestamp":1775787836745,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with narcolepsy or idiopathic hypersomnia (IH) are at increased risk of driving accidents. Both excessive daytime sleepiness, i.e. unwanted sleep episodes during the day, and disturbed vigilance are core features of these disorders. We tested on\u2010the\u2010road driving performance of patients with narcolepsy or IH coming in for a routine driving fitness evaluation and examined: (1) correlations between driving performance and the Maintenance of Wakefulness Test (MWT), Sustained Attention to Response Task (SART) and Psychomotor Vigilance Test (PVT) as objective tests; (2) the predictive power of the MWT and SART for increased risk of impaired driving; (3) the best set of objective predictors for increased risk of impaired driving. Participants were 44 patients (aged 18\u201375\u00a0years) with narcolepsy type 1 (NT1), type 2 (NT2) or IH. They completed the MWT, SART, PVT, a subjective sleepiness questionnaire, and a standardised on\u2010the\u2010road driving test. The standard deviation of the lateral position (SDLP) was used as outcome measure of driving performance. The MWT had low correlation with the SDLP (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.41 to \u22120.49, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The SART and PVT had low correlations with SDLP (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.30 and <jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.39, respectively, both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The predictive power of MWT for an increased risk of impaired driving was significant, but low (area under the curve\u00a0=\u00a00.273, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012), and non\u2010significant for SART. We conclude that in our present group, none of the tests had adequate ability to predict impaired driving, questioning their use for clinical driving fitness evaluation in narcolepsy and IH. Real\u2010time monitoring of sleepiness while driving seems more promising in these patients.<\/jats:p>","DOI":"10.1111\/jsr.13518","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:53:21Z","timestamp":1636530801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparing objective wakefulness and vigilance tests to on\u2010the\u2010road driving performance in narcolepsy and idiopathic hypersomnia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5169-9830","authenticated-orcid":false,"given":"Denise","family":"Bijlenga","sequence":"first","affiliation":[{"name":"Sleep\u2010Wake Centre Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Urbanus","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake Centre Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-4519","authenticated-orcid":false,"given":"Nick N. 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M.","family":"van der Sluiszen","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Overeem","sequence":"additional","affiliation":[{"name":"Centre for Sleep Medicine Kempenhaeghe  Heeze the Netherlands"},{"name":"Department of Electrical Engineering Eindhoven University of Technology  Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.","family":"Ramaekers","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek","family":"Vermeeren","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert Jan","family":"Lammers","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake Centre Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede the Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207459008994241"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.581"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26367"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0001\u20104575(00)00013\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70225\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3758\/BF03200977","article-title":"Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations","volume":"17","author":"Dinges D. 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