{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:13:18Z","timestamp":1790763198060,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sleepwalking is a common non\u2010rapid eye movement (NREM) parasomnia and a significant cause of sleep\u2010related injuries. While evidence suggest that the occurrence of this condition is partly determined by genetic factors, its pattern of inheritance remains unclear, and few molecular studies have been conducted. One promising candidate is the adenosine deaminase (<jats:italic>ADA<\/jats:italic>) gene. Adenosine and the ADA enzyme play an important role in the homeostatic regulation of NREM sleep. In a single sleepwalking family, genome\u2010wide analysis identified a locus on chromosome 20, where <jats:italic>ADA<\/jats:italic> lies. In this study, we examined if variants in the <jats:italic>ADA<\/jats:italic> gene were associated with sleepwalking. In total, 251 sleepwalking patients were clinically assessed, and DNA samples were compared to those from 94 unaffected controls. Next\u2010generation sequencing of the whole <jats:italic>ADA<\/jats:italic> gene was performed. Bio\u2010informatic analysis enabled the identification of variants and assessed variants enrichment in our cohort compared to controls. We detected 25 different coding and non\u2010coding variants, of which 22 were found among sleepwalkers. None were enriched in the sleepwalking population. However, many missense variants were predicted as likely pathogenic by at least two in silico prediction algorithms. This study involves the largest sleepwalking cohort in which the role of a susceptibility gene was investigated. Our results did not reveal an association between <jats:italic>ADA<\/jats:italic> gene and sleepwalking, thus ruling out the possibility of <jats:italic>ADA<\/jats:italic> as a major genetic factor for this condition. Future work is needed to identify susceptibility genes.<\/jats:p>","DOI":"10.1111\/jsr.13537","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T02:43:35Z","timestamp":1639622615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Does the adenosine deaminase (<i>ADA<\/i>) gene confer risk of sleepwalking?"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-9030","authenticated-orcid":false,"given":"Simon","family":"Fournier","sequence":"first","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine H\u00f4pital du Sacr\u00e9\u2010C\u0153ur (CIUSSS\u2010NIM)  Montr\u00e9al Canada"},{"name":"Department of Neuroscience Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"Sleep Unit 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