{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:02:13Z","timestamp":1775916133497,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Modulation of slow\u2010wave activity, either via pharmacological sleep induction by administering sodium oxybate or sleep restriction followed by a strong dissipation of sleep pressure, has been associated with preserved posttraumatic cognition and reduced diffuse axonal injury in traumatic brain injury rats. Although these classical strategies provided promising preclinical results, they lacked the specificity and\/or translatability needed to move forward into clinical applications. Therefore, we recently developed and implemented a rodent auditory stimulation method that is a scalable, less invasive and clinically meaningful approach to modulate slow\u2010wave activity by targeting a particular phase of slow waves. Here, we assessed the feasibility of down\u2010phase targeted auditory stimulation of slow waves and evaluated its comparative modulatory strength in relation to the previously employed slow\u2010wave activity modulators in our rat model of traumatic brain injury. Our results indicate that, in spite of effectively reducing slow\u2010wave activity in both healthy and traumatic brain injury rats via down\u2010phase targeted stimulation, this method was not sufficiently strong to counteract the boost in slow\u2010wave activity associated with classical modulators, nor to alter concomitant posttraumatic outcomes. Therefore, the usefulness and effectiveness of auditory stimulation as potential standalone therapeutic strategy in the context of traumatic brain injury warrants further exploration.<\/jats:p>","DOI":"10.1111\/jsr.13615","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T03:43:57Z","timestamp":1651031037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Down\u2010phase auditory stimulation is not able to counteract pharmacologically or physiologically increased sleep depth in traumatic brain injury rats"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-3668","authenticated-orcid":false,"given":"Carlos G.","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"M\u00fcllner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-1978","authenticated-orcid":false,"given":"Christian R.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"},{"name":"University Center of Competence Sleep &amp; Health Zurich (CRPP) University of Zurich  Zurich Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ)  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun R.","family":"Ginde","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedef","family":"Kollarik","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta M.","family":"Morawska","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-7933","authenticated-orcid":false,"given":"Daniela","family":"Noain","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich, University of Zurich  Zurich Switzerland"},{"name":"University Center of Competence Sleep &amp; Health Zurich (CRPP) University of Zurich  Zurich Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ)  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8070137"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4001"},{"key":"e_1_2_9_5_1","unstructured":"Scientific reports 10 Repetitive mild traumatic brain injury alters glymphatic clearance rates in limbic structures of adolescent female rats"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4618"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(88)90157-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15405"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101438"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"Gennarelli T. 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