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It results from an excessive stimulation of eccrine sweat glands in the skin by the sympathetic nervous system. Hyperhidrosis may be primary or secondary to an underlying cause. Nocturnal hyperhidrosis is associated with different sleep disorders, such as obstructive sleep apnea, insomnia, restless legs syndrome\/periodic limb movement during sleep and narcolepsy. The major cause of the hyperhidrosis is sympathetic overactivity and, in the case of narcolepsy type 1, orexin deficiency may also contribute. In this narrative review, we will provide an outline of the possible mechanisms underlying sudomotor dysfunction and the resulting nocturnal hyperhidrosis in these different sleep disorders and explore its clinical relevance.<\/jats:p>","DOI":"10.1111\/jsr.13660","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T05:44:48Z","timestamp":1655358288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hyperhidrosis in sleep disorders \u2013 A narrative review of mechanisms and clinical significance"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-2289","authenticated-orcid":false,"given":"Juan","family":"Idiaquez","sequence":"first","affiliation":[{"name":"Departamento de Neurolog\u00eda, Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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