{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:48:07Z","timestamp":1788486487685,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH109638"],"award-info":[{"award-number":["R01MH109638"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Heart rate variability (HRV) can be used to assess changes in output of the parasympathetic nervous system (PNS). Considering that patients with post\u2010traumatic stress disorder (PTSD) often experience disturbances in sleep, arousal, and autonomic functioning, we sought to explore the association of PNS activity during sleep with hyperarousal symptoms of PTSD. Because a broad literature supports the importance of rapid eye movement (REM) sleep in PTSD, REM\u2010sleep features were specifically examined as predictors of PTSD symptom severity. A total of 90 participants, primarily civilian and female, aged 18\u201340\u2009years who had experienced a traumatic event in the last 2\u2009years, underwent an ambulatory polysomnography (PSG) acclimation night followed by a second PSG night from which sleep physiological measures were computed. Participants underwent an ambulatory polysomnography (PSG) acclimation night followed by a second PSG night from which sleep physiological measures were computed. PTSD severity was measured using the PTSD Checklist for the\n                    <jats:italic>Diagnostic and Statistical Manual of Mental Disorders<\/jats:italic>\n                    , Fifth Edition (PCL\u20105). Dependent variables were total PCL\u20105 score as well as its hyperarousal symptom subscore. Predictors included REM latency, percentage, density, segment length, and an index of parasympathetic tone (root mean square of the successive differences in the R\u2013R interval or RMSSD). Hierarchical regression models were conducted to analyse the association of REM features with PCL\u20105 total and hyperarousal subscales. Using hierarchical regression, REM\u2010sleep RMSSD accounted for a significant proportion of the variation in outcome variables, even when accounting for other REM\u2010sleep features. The present findings support hypothesised relationships between PTSD symptomatology and REM\u2010sleep physiology and, specifically, that lowered parasympathetic tone in REM may be an important associate of the hyperarousal symptom cluster in PTSD.\n                  <\/jats:p>","DOI":"10.1111\/jsr.13685","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T02:45:56Z","timestamp":1659408356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Rapid eye movement sleep parasympathetic activity predicts wake hyperarousal symptoms following a traumatic event"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-7108","authenticated-orcid":false,"given":"Carolina","family":"Daffre","sequence":"first","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn I.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovi R. S.","family":"Nazareno","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-4746","authenticated-orcid":false,"given":"Thomas","family":"M\u00e4der","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Zurich  Z\u00fcrich Switzerland"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehye","family":"Seo","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Department of Brain and Cognitive Engineering Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod P.","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Athinoula A. 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Martinos Center for Biomedical Imaging  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-7570","authenticated-orcid":false,"given":"Edward F.","family":"Pace\u2010Schott","sequence":"additional","affiliation":[{"name":"Athinoula A. 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Blake DD Schnurr PP Kaloupek DG Marx BP Keane TM.(2013)The clinician\u2010administered PTSD scale for DSM\u20105 (CAPS\u20105). 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