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This study aimed to meta\u2010analyse the impact of three kinds of nasal interfaces with both network meta\u2010analysis and pairwise comparison. PubMed, EMBASE, CENTRAL and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> were systematically searched from inception to December 2020 for studies that compared the three types of nasal interfaces for treating obstructive sleep apnea with continuous positive airway pressure. The outcomes were residual apnea\u2013hypopnea index, continuous positive airway pressure, and nightly average usage. The network meta\u2010analysis was conducted using multivariate random\u2010effects in a frequentist framework where three interfaces were ranked with the surface under the cumulative ranking probabilities. The pairwise comparison was conducted using random\u2010effects meta\u2010analysis. Twenty\u2010nine articles comprising 6378 participants were included. 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