{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:44:50Z","timestamp":1788669890526,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010IDEX\u201002"],"award-info":[{"award-number":["ANR\u201015\u2010IDEX\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This SERVE\u2010HF (Treatment of Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure) sub study analysis evaluated polysomnography (PSG) data in patients with heart failure with reduced ejection fraction (HFrEF) and predominant central sleep apnea (CSA) randomised to guideline\u2010based medical therapy, with or without adaptive servo ventilation (ASV). Patients underwent full overnight PSG at baseline and at 12\u2009months. All PSG recordings were analysed by a core laboratory. Only data for patients with baseline and 3\u2010 or 12\u2010month values were included. The sub study included 312 patients; the number with available PSG data differed for each variable (94\u2013103 in the control group, 77\u201399 in the ASV group). After 12\u2009months, baseline\u2010adjusted respiratory measures were significantly better in the ASV group versus control. Although some between\u2010group differences in sleep measures were seen at 12\u2009months (e.g., better sleep efficiency in the ASV group), these were unlikely to be clinically significant. The number of periodic leg movements during sleep (PLMS) increased in the ASV group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.039). At 12\u2009months, the respiratory arousal index was significantly lower in the ASV versus control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whilst the PLMS\u2010related arousal index was significantly higher in the ASV group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 versus control). ASV attenuated the respiratory variables characterising sleep apnea in patients with HFrEF and predominant CSA in SERVE\u2010HF. Sleep quality improvements during ASV therapy were small and unlikely to be clinically significant. The increase in PLMS and PLMS\u2010related arousals during ASV warrants further investigation, particularly relating to their potential association with increased cardiovascular risk.<\/jats:p>","DOI":"10.1111\/jsr.13694","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T01:48:45Z","timestamp":1657936125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the <scp>SERVE\u2010HF<\/scp> major sub study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-6529","authenticated-orcid":false,"given":"Renaud","family":"Tamisier","sequence":"first","affiliation":[{"name":"University Grenoble Alpes, Inserm, HP2 Laboratory, Pole Thorax et Vaisseaux CHU Grenoble Alpes  Grenoble 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