{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:48:26Z","timestamp":1787168906135,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108001"],"award-info":[{"award-number":["82020108001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The hypocretin neurons in the lateral hypothalamus are connected not only to brain alertness systems but also to brainstem nuclei that regulate blood pressure and heart rate. The premise is that regulation of blood pressure and heart rate is altered and affected by methylphenidate, a stimulant drug in children with narcolepsy with cataplexy. The changes in 24\u2010hr ambulatory systolic and diastolic blood pressure and heart rate were compared among pre\u2010treated narcolepsy with cataplexy patients (40 males, 10 females), with mean age 10.4\u2009\u00b1\u20093.5\u2009years (M\u2005\u00b1\u2005SD, range 5\u201317\u2009years) with values from 100 archival age\u2013sex\u2013body mass index matched controls. Patients had a lower diurnal systolic blood pressure (\u22126.5\u2009mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.000) but higher heart rate (+11.0\u00a0bpm;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.000), particularly evident in the waketime, while diastolic blood pressure was comparable. With methylphenidate (18\u2009mg sustained release at 08:00\u2005hours), patients with narcolepsy with cataplexy had higher systolic blood pressure (+4.6\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015), diastolic blood pressure (+3.3\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.005) and heart rate (+7.1\u00a0bpm,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.028) during wake time, but nighttime cardiovascular values were unchanged from pre\u2010treated values; amplitude variation in cardiovascular values was unchanged over 24\u2005hr. In conclusion, children with narcolepsy with cataplexy had downregulation blood pressure profile but a higher heart rate, and lesser non\u2010dipping profiles. Daytime methylphenidate treatment increases only waketime blood pressure and further elevated heart rate values.\n                  <\/jats:p>","DOI":"10.1111\/jsr.13736","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T23:20:10Z","timestamp":1664234410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diurnal changes in blood pressure and heart rate in children with narcolepsy with cataplexy"],"prefix":"10.1111","volume":"32","author":[{"given":"Jingyu","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"},{"name":"Department of Respiratory and Critical Care Medicine Binzhou Medical University Hospital  Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Binzhou Medical University Hospital  Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingman P.","family":"Strohl","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine Case Western Reserve University, and Cleveland Louis Stokes VA Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-8457","authenticated-orcid":false,"given":"Fang","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"International classification of sleep disorders, 2nd ed: Diagnostic and coding manual","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"e_1_2_11_3_1","volume-title":"The international classification of sleep disorders\u2013third edition (ICSD\u20103)","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.03.020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00116-7"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"127","article-title":"Accuracy of the SpaceLabs 90207 ambulatory blood pressure monitor in children and adolescents","volume":"1","author":"Belsha C. 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