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The group was subdivided into those receiving monotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a03,594) and those receiving dual combined therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a02,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta\u2010blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta\u2010blocker was associated with lower systolic blood pressure, particularly in non\u2010obese middle\u2010aged males with hypertension. Conversely, the combination of a beta\u2010blocker and a diuretic was associated with lower systolic and diastolic blood pressure in hypertensive patients with moderate\u2013severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross\u2010sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in hypertensive OSA patients. Controlled trials are warranted.<\/jats:p>","DOI":"10.1111\/jsr.13811","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T05:38:35Z","timestamp":1671601115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (<scp>ESADA)<\/scp> cohort \u2013 towards precision medicine"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-7938","authenticated-orcid":false,"given":"Sven","family":"Svedmyr","sequence":"first","affiliation":[{"name":"Department of Sleep Medicine Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Center for Sleep and Vigilance Disorders, Sahlgrenska Academy Gothenburg University  Gothenburg 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