{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:48:18Z","timestamp":1775195298686,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008493","name":"V\u00e4in\u00f6 ja Laina Kiven S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The purpose of this study was to investigate how the blood pressure increase observed during menopausal transition is affected by sleep\u2010disordered breathing and the menopause itself. Further, we aimed to find new sleep\u2010disordered breathing related markers that would predict the development of hypertension. Sixty\u2010four community\u2010dwelling premenopausal women aged 45\u201347\u2009years were studied. Polysomnography, serum follicle stimulating hormone, forced expiratory volume in 1\u2009s, and a physical examination were performed at baseline and again after 10\u2009years of follow\u2010up. Indices for sleep apnea\/hypopnea and inspiratory flow\u2010limitation were determined. Regression models were used to study the relationships between variables. Changes in the apnea\u2010hypopnea index or serum follicle stimulating hormone were not significant for blood pressure change. An increase in morning blood pressure during the follow\u2010up period was associated with a body mass\u2010index increase. An increase in evening blood pressure was associated with an increase in inspiratory flow\u2010limitation during non\u2010rapid eye movement sleep. Incident hypertension during the follow\u2010up was associated with hypopnea (median hypopnea index 7.6\/h, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048) during rapid eye movement sleep at baseline. Users of menopausal hormone therapy had a lower rapid eye movement sleep apnea\u2010hypopnea index (1.6\/h vs. 6.9\/h, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026) at baseline whereas at follow\u2010up users and non\u2010users did not differ in any way. The progression of menopause or the use of menopausal hormone therapy had a minimal effect on blood pressure in our population. The effects of inspiratory flow\u2010limitation on blood pressure profile should be studied further.<\/jats:p>","DOI":"10.1111\/jsr.13829","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T03:32:29Z","timestamp":1675481549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evolution of sleep\u2010disordered breathing and blood pressure during menopausal transition"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-3475","authenticated-orcid":false,"given":"Ville","family":"Rimpil\u00e4","sequence":"first","affiliation":[{"name":"Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lampio","sequence":"additional","affiliation":[{"name":"Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology University of Turku  Turku Finland"},{"name":"Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-8842","authenticated-orcid":false,"given":"Nea","family":"Kalleinen","sequence":"additional","affiliation":[{"name":"Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology University of Turku  Turku Finland"},{"name":"Heart Center, Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Biostatistics, University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arho","family":"Virkki","sequence":"additional","affiliation":[{"name":"Department of Mathematics and 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