{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:35:07Z","timestamp":1790638507449,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["07 LVIE 004"],"award-info":[{"award-number":["07 LVIE 004"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["APP1135727"],"award-info":[{"award-number":["APP1135727"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (BDNF) is important for sleep physiology. This study investigates whether <jats:italic>BDNF<\/jats:italic> variants and promoter I methylation may be implicated in sleep disturbances in older adults. Genotyping was performed for seven <jats:italic>BDNF<\/jats:italic> single nucleotide polymorphisms (SNPs) in 355 community\u2010dwelling older adults (aged \u226565\u2009years) and <jats:italic>BDNF<\/jats:italic> exon 1 promoter methylation was measured in blood samples at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a0153). Self\u2010reported daytime sleepiness and insomnia, ambulatory polysomnography measures of sleep continuity and architecture, and psychotropic drug intake were assayed during follow\u2010up. Logistic regression adjusted for age, sex, comorbidities, body mass index, and psychotropic drug intake. Associations were found specifically between wake time after sleep onset (WASO) and four SNPs in the participants not taking psychotropic drugs, whereas in those taking drugs, the associations were either not significant (<jats:italic>rs6265<\/jats:italic> and <jats:italic>rs7103411)<\/jats:italic> or in the reverse direction (<jats:italic>rs11030101<\/jats:italic> and <jats:italic>rs28722151)<\/jats:italic>. Higher <jats:italic>BDNF<\/jats:italic> methylation levels were found at most CpG units in those with long WASO and this varied according to psychotropic drug use. The reference group with short WASO not taking drugs showed the lowest methylation levels and the group with long WASO taking treatment, the highest levels. Some SNPs also modified the associations, the participants carrying the low\u2010risk genotype having the lower methylation levels. This genetic and epigenetic study demonstrated blood <jats:italic>BDNF<\/jats:italic> promoter methylation to be a potential biomarker of prolonged nocturnal awakenings in older people. Our results suggest the modifying effect of psychotropic drugs and <jats:italic>BDNF<\/jats:italic> genetic variants in the associations between methylation and WASO.<\/jats:p>","DOI":"10.1111\/jsr.13838","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T03:07:25Z","timestamp":1675480045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Brain\u2010derived neurotrophic factor (<scp><i>BDNF<\/i>)<\/scp> variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults"],"prefix":"10.1111","volume":"32","author":[{"given":"Marie\u2010Laure","family":"Ancelin","sequence":"first","affiliation":[{"name":"INM, INSERM Univ Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Jaussent","sequence":"additional","affiliation":[{"name":"INM, INSERM Univ Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[{"name":"INM, INSERM Univ Montpellier  Montpellier France"},{"name":"Institut du Cerveau Trocad\u00e9ro  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Besset","sequence":"additional","affiliation":[{"name":"INM, INSERM Univ Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6506","authenticated-orcid":false,"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"INM, INSERM Univ Montpellier  Montpellier France"},{"name":"Sleep\u2010Wake Disorders Unit Department of Neurology, Gui\u2010de\u2010Chauliac Hospital  CHU Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.95"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-121228"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1389-9457(00)00065-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.05.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0348-04.2004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1321908"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12577"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Jgp.0000249385.50101.67"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021055617738"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.12.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.10"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4432-15.2016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.09.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23380"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112157"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2020.107353"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32616"},{"key":"e_1_2_9_21_1","volume-title":"The AASM manual for the scoring of sleep and associated events: Rules, terminology, and technical specifications","author":"Iber C.","year":"2007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.114"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu273"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-212"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.11.005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2017.09.001"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084806"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.12.071"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.12.020"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1240"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.07.008"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02914-1"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299721"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.2.147"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000266670.35219.0c"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2015.1131327"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.025"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00156"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.07.025"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.13838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.13838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.13838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T10:37:47Z","timestamp":1692355067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.13838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jsr.13838"],"URL":"https:\/\/doi.org\/10.1111\/jsr.13838","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"assertion":[{"value":"2022-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13838"}}