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To provide fresh guidelines for the treatment of OSA from a co\u2010morbidity standpoint, we conducted a systematic search of Web of Science, PubMed, EMBASE, and the Cochrane Library for articles published from inception up to 2 May 2023. Fourteen original studies of patients with OSA with cardiovascular co\u2010morbidities and who received related treatment were included in the analysis. We found that diuretic treatment can reduce the apnea\u2013hypopnea index in patients with OSA and hypertension (\u221219.41\/h, <jats:italic>p<\/jats:italic>\u2009=\u20091.0\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>), aldosterone\u2010angiotensin inhibitors also have a 9.19\/h reduction (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), while the effect of renal sympathetic denervation is insignificant (\u22122.32\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.19). The short\u2010term treatment (&lt;4\u2009weeks) did not show an improvement (\u22122.72\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.16), while long\u2010term treatment (&gt;4\u2009weeks) produced surprising outcomes (\u221212.78\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Patients with milder disease (baseline AHI\u2009&lt;\u200935\/h) had insignificant improvements (\u22121.05\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.46), whereas those with more severe disease (baseline AHI\u2009&gt;\u200935\/h) could achieve satisfactory outcomes (\u221214.74\/h, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). In addition, it also showed some improvement in the oxygen desaturation index and blood oxygen. Our results support the additional benefit of antihypertensive treatment for OSA symptoms, and the efficacy can be affected by different therapy, treatment duration, and severity levels. It could be useful in developing clinical therapy, educating patients, and exploring interaction mechanisms. The proposal was registered with PROSPERO (CRD42022351206).<\/jats:p>","DOI":"10.1111\/jsr.13965","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:39:50Z","timestamp":1688603990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of different anti\u2010cardiovascular disease treatments on the severity of obstructive sleep apnea"],"prefix":"10.1111","volume":"33","author":[{"given":"Ruihan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Xiangya School of Medicine Central South University  Changsha Hunan 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