{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:14:32Z","timestamp":1787948072573,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100023253","name":"Angior Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012698","name":"Jack Brockhoff Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children with Down syndrome are at increased risk of obstructive sleep disordered breathing, which has deleterious effects on daytime functioning. We aimed to examine the effects of treatment of sleep disordered breathing on sleep quality and daytime functioning in children with Down syndrome, and hypothesised that these would be improved. Thirty\u2010four children completed a baseline study and a follow\u2010up 2\u2009years later. Measures at both time points included 7\u2009days of actigraphy and parents completed a number of questionnaires assessing sleep, behaviour, daytime functioning, and quality of life. All children had overnight polysomnography at baseline; 15 children (44%) were treated. At baseline the treated group had more severe sleep disordered breathing compared with the untreated group: obstructive apneoa\u2013hypopnoea index 29.3\u2009\u00b1\u200938.2 events\/h versus 3.3\u2009\u00b1\u20095.2 events\/h (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Actigraphy showed no significant differences in total sleep time, sleep efficiency, sleep schedules from baseline to follow up in either group. The sleep disturbance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and total problems (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) scales on the OSA\u201018 and the sleep disordered breathing subscale on the Paediatric Sleep Problem Survey Instrument (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) improved in the treated children. There were no changes in any measure in the untreated children. Treatment of sleep disordered breathing improves symptoms, sleep disturbance and quality of life in children with Down syndrome, but has no demonstrable impact on actigraphic sleep measures or daytime behaviour or function. In contrast, children who were not treated, despite having less severe disease at baseline, had increased sleep disruption and no change in quality of life.<\/jats:p>","DOI":"10.1111\/jsr.13970","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T14:01:13Z","timestamp":1687615273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Follow\u2010up of children with Down syndrome and sleep disordered breathing and the effects of treatment on actigraphically recorded sleep, quality of life, behaviour, and daytime functioning"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-0461","authenticated-orcid":false,"given":"Rosemary S. 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