{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:46:22Z","timestamp":1788691582723,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3E5D5064110"],"award-info":[{"award-number":["2019M3E5D5064110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1066232"],"award-info":[{"award-number":["2022R1F1A1066232"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000209494"],"award-info":[{"award-number":["RS\u20102023\u201000209494"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Continuous positive airway pressure (CPAP) is the primary therapeutic modality for obstructive sleep apnea (OSA) management. However, despite efforts to encourage patients to comply with CPAP usage, long\u2010term adherence remains low. Consequently, surgical intervention for OSA is considered a secondary option for patients who exhibit non\u2010compliance with CPAP. Therefore, we conducted systematic review and meta\u2010analysis assessed the relative effectiveness of hypoglossal nerve stimulation (HNS) treatment and alternative surgical interventions for managing OSA. Five databases were searched. Studies were included if they measured polysomnography parameters and assessed sleep apnea\u2010related quality of life (Epworth Sleepiness Scale [ESS]) both before and after HNS, and compared these outcomes with control, CPAP, or airway surgery (uvulopalatopharyngoplasty, expansion sphincter pharyngoplasty, or tongue base surgery) groups. A total of 10 studies (2209 patients) met the inclusion criteria. Compared to other airway surgeries, the rates of post\u2010treatment apnea\u2013hypopnea index (AHI)\u2009&lt;\u200910 and &lt;\u200915\u2009events\/h were significantly lower in the HNS group (odds ratio [OR] 5.33, 95% confidence interval [CI] 1.21\u201323.42; and 2.73, 95% CI 1.30\u20135.71, respectively). Additionally, postoperative AHI was significantly lower in the HNS group than in all other airway surgery groups (AHI: mean difference [MD] \u22128.00, 95% CI \u221212.03 to\u22123.97\u2009events\/h). However, there were no significant differences in the rate of post\u2010treatment AHI\u2009&lt;\u20095\u2009events\/h (OR 1.93, 95% CI 0.74\u20135.06) or postoperative ESS score (MD 0.40, 95% CI\u22121.52 to 2.32) between the two groups. HNS is an effective option for selected patients with moderate\u2010to\u2010severe OSA and CPAP intolerance.<\/jats:p>","DOI":"10.1111\/jsr.14017","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:26:02Z","timestamp":1693812362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative effectiveness of hypoglossal nerve stimulation and alternative treatments for obstructive sleep apnea: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Do Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun\u2010Jeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdullah","family":"Basurrah","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine, Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-7820","authenticated-orcid":false,"given":"Se Hwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.10.1408"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817696503"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23079"},{"key":"e_1_2_10_5_1","first-page":"899","article-title":"Upper airway stimulation for obstructive sleep apnea: Past, present, and future","volume":"38","author":"Dedhia R. C.","year":"2015","journal-title":"Sleep"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0204PP"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817691475"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01405-2018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02663-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420953178"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418771395"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6726"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27484"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.18787\/jr.2022.00407"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.01718"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200403000-00012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.00052"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202001-015OC"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208691"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0156-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.01.003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.03.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103035"},{"key":"e_1_2_10_26_1","article-title":"Surgery for obstructive sleep apnoea","volume":"19","author":"Sundaram S.","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.06.020"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-119MG"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814544445"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T05:03:21Z","timestamp":1715663001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jsr.14017"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14017","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]},"assertion":[{"value":"2023-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14017"}}