{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:56:26Z","timestamp":1791647786101,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009886","name":"American Academy of Sleep Medicine","doi-asserted-by":"publisher","award":["269\u2010FP\u201022"],"award-info":[{"award-number":["269\u2010FP\u201022"]}],"id":[{"id":"10.13039\/100009886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R21MD012738\u201002"],"award-info":[{"award-number":["5R21MD012738\u201002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL007901\u201023"],"award-info":[{"award-number":["5T32HL007901\u201023"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F32HL15255"],"award-info":[{"award-number":["F32HL15255"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01AG070867"],"award-info":[{"award-number":["R01AG070867"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL155395"],"award-info":[{"award-number":["R01HL155395"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL161012"],"award-info":[{"award-number":["R01HL161012"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL135818"],"award-info":[{"award-number":["R35HL135818"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Irregular sleep and non\u2010optimal sleep duration separately have been shown to be associated with increased disease and mortality risk. We used data from the prospective cohort Multi\u2010Ethnic Study of Atherosclerosis sleep study (2010\u20132013) to investigate: do aging adults whose sleep is objectively high in regularity in timing and duration, and of sufficient duration tend to have increased survival compared with those whose sleep is lower in regularity and duration, in a diverse US sample? At baseline, sleep was measured by 7\u2010day wrist actigraphy, concurrent with at\u2010home polysomnography and questionnaires. Objective metrics of sleep regularity and duration from actigraphy were used for statistical clustering using sparse k\u2010means clustering. Two sleep patterns were identified: \u201cregular\u2010optimal\u201d (average duration: 7.0\u2009\u00b1\u20091.0\u2009hr obtained regularly) and \u201cirregular\u2010insufficient\u201d (duration: 5.8\u2009\u00b1\u20091.4\u2009hr obtained with twice the irregularity). Using proportional hazard models with multivariate adjustment, we estimated all\u2010cause mortality hazard ratios. Among 1759 participants followed for a median of 7.0\u2009years (Q1\u2013Q3, 6.4\u20137.4\u2009years), 176 deaths were recorded. The \u201cregular\u2010optimal\u201d group had a 39% lower mortality hazard than did the \u201cirregular\u2010insufficient\u201d sleep group (hazard ratio [95% confidence interval]: 0.61 [0.45, 0.83]) after adjusting for socio\u2010demographics, lifestyle, medical comorbidities and sleep disorders. In conclusion, a \u201cregular\u2010optimal\u201d sleep pattern was significantly associated with a lower hazard of all\u2010cause mortality. The regular\u2010optimal phenotype maps behaviourally to regular bed and wake times, suggesting sleep benefits of adherence to recommended healthy sleep practices, with further potential benefits for longevity.<\/jats:p>","DOI":"10.1111\/jsr.14048","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:14:51Z","timestamp":1695784491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Objectively regular sleep patterns and mortality in a prospective cohort: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-9833","authenticated-orcid":false,"given":"Joon","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew O.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Castro\u2010Diehl","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarvis T.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Bertisch","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun M.","family":"Purcell","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013128"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6602"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.06.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003200"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.5.585"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v061.i06"},{"issue":"6","key":"e_1_2_10_12_1","first-page":"877","article-title":"Racial\/ethnic differences in sleep disturbances: The multi\u2010ethnic study of atherosclerosis (MESA)","volume":"38","author":"Chen X.","year":"2015","journal-title":"Sleep"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12393"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwab232"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad048"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2023.02.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.03.010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2006.11.025"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa175"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100233"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.054"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0596"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy057"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00355-3"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.06.047"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.2.131"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.04.016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2021.113800"},{"issue":"1","key":"e_1_2_10_31_1","first-page":"1","article-title":"Sleep health composites are associated with the risk of heart disease across sex and race","volume":"12","author":"Lee S.","year":"2022","journal-title":"Scientific Reports"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpac005"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2453"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000151743.58067.f0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2021.721919"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32402-5"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.02.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-1025-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6096"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2022.08.010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.13"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2699"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03171-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808180106"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-0555-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5464"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00293"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac015"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.265.4.R846"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545979"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2003.10.002"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-020-01324-w"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T07:03:30Z","timestamp":1705993410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jsr.14048"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14048","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]},"assertion":[{"value":"2023-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14048"}}